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LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection

Despite various drugs work against Candida, candidiasis represents clinical management challenges worldwide due to the rising incidence and recurrence rate, as well as epidemics, of new drug-resistant pathogens. Recent insights into interactions between Candida and hosts contribute to exploring nove...

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Detalles Bibliográficos
Autores principales: Wang, Ye, Xu, Hongdan, Chen, Na, Yang, Jin, Zhou, Hongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954347/
https://www.ncbi.nlm.nih.gov/pubmed/35335994
http://dx.doi.org/10.3390/pharmaceutics14030621
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author Wang, Ye
Xu, Hongdan
Chen, Na
Yang, Jin
Zhou, Hongmei
author_facet Wang, Ye
Xu, Hongdan
Chen, Na
Yang, Jin
Zhou, Hongmei
author_sort Wang, Ye
collection PubMed
description Despite various drugs work against Candida, candidiasis represents clinical management challenges worldwide due to the rising incidence and recurrence rate, as well as epidemics, of new drug-resistant pathogens. Recent insights into interactions between Candida and hosts contribute to exploring novel therapeutic strategies, termed host-directed therapies (HDTs). HDTs are viable adjuncts with good efficacy for the existing standard antifungal regimens. However, HDTs induce other response unintendedly, thus requiring molecular targets with highly specificity. Long noncoding RNAs (lncRNAs) with highly specific expression patterns could affect biological processes, including the immune response. Herein, this review will summarize recent advances of HDTs based on the Candida–host interaction. Especially, the findings and application strategies of lncRNAs related to the host response are emphasized. We propose it is feasible to target lncRNAs to modulate the host defense during Candida infection, which provides a new perspective in identifying options of HDTs for candidiasis.
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spelling pubmed-89543472022-03-26 LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection Wang, Ye Xu, Hongdan Chen, Na Yang, Jin Zhou, Hongmei Pharmaceutics Review Despite various drugs work against Candida, candidiasis represents clinical management challenges worldwide due to the rising incidence and recurrence rate, as well as epidemics, of new drug-resistant pathogens. Recent insights into interactions between Candida and hosts contribute to exploring novel therapeutic strategies, termed host-directed therapies (HDTs). HDTs are viable adjuncts with good efficacy for the existing standard antifungal regimens. However, HDTs induce other response unintendedly, thus requiring molecular targets with highly specificity. Long noncoding RNAs (lncRNAs) with highly specific expression patterns could affect biological processes, including the immune response. Herein, this review will summarize recent advances of HDTs based on the Candida–host interaction. Especially, the findings and application strategies of lncRNAs related to the host response are emphasized. We propose it is feasible to target lncRNAs to modulate the host defense during Candida infection, which provides a new perspective in identifying options of HDTs for candidiasis. MDPI 2022-03-11 /pmc/articles/PMC8954347/ /pubmed/35335994 http://dx.doi.org/10.3390/pharmaceutics14030621 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Ye
Xu, Hongdan
Chen, Na
Yang, Jin
Zhou, Hongmei
LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection
title LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection
title_full LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection
title_fullStr LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection
title_full_unstemmed LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection
title_short LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection
title_sort lncrna: a potential target for host-directed therapy of candida infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954347/
https://www.ncbi.nlm.nih.gov/pubmed/35335994
http://dx.doi.org/10.3390/pharmaceutics14030621
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