A Sub-Micromolar MraY(AA) Inhibitor with an Aminoribosyl Uridine Structure and a (S,S)-Tartaric Diamide: Synthesis, Biological Evaluation and Molecular Modeling

New inhibitors of the bacterial tranferase MraY are described. Their structure is based on an aminoribosyl uridine scaffold, which is known to be important for the biological activity of natural MraY inhibitors. A decyl alkyl chain was introduced onto this scaffold through various linkers. The synth...

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Detalles Bibliográficos
Autores principales: Oliver, Martin, Le Corre, Laurent, Poinsot, Mélanie, Bosco, Michaël, Wan, Hongwei, Amoroso, Ana, Joris, Bernard, Bouhss, Ahmed, Calvet-Vitale, Sandrine, Gravier-Pelletier, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954382/
https://www.ncbi.nlm.nih.gov/pubmed/35335131
http://dx.doi.org/10.3390/molecules27061769

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