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Role of Pharmacogenetics in the Treatment of Acute Myeloid Leukemia: Systematic Review and Future Perspectives
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by remarkable toxicity and great variability in response to treatment. Plenteous pharmacogenetic studies have already been published for classical therapies, such as cytarabine or anthracyclines, but such studies remain scarce for...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954545/ https://www.ncbi.nlm.nih.gov/pubmed/35335935 http://dx.doi.org/10.3390/pharmaceutics14030559 |
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author | Pinto-Merino, Álvaro Labrador, Jorge Zubiaur, Pablo Alcaraz, Raquel Herrero, María José Montesinos, Pau Abad-Santos, Francisco Saiz-Rodríguez, Miriam |
author_facet | Pinto-Merino, Álvaro Labrador, Jorge Zubiaur, Pablo Alcaraz, Raquel Herrero, María José Montesinos, Pau Abad-Santos, Francisco Saiz-Rodríguez, Miriam |
author_sort | Pinto-Merino, Álvaro |
collection | PubMed |
description | Acute myeloid leukemia (AML) is a heterogeneous disease characterized by remarkable toxicity and great variability in response to treatment. Plenteous pharmacogenetic studies have already been published for classical therapies, such as cytarabine or anthracyclines, but such studies remain scarce for newer drugs. There is evidence of the relevance of polymorphisms in response to treatment, although most studies have limitations in terms of cohort size or standardization of results. The different responses associated with genetic variability include both increased drug efficacy and toxicity and decreased response or resistance to treatment. A broad pharmacogenetic understanding may be useful in the design of dosing strategies and treatment guidelines. The aim of this study is to perform a review of the available publications and evidence related to the pharmacogenetics of AML, compiling those studies that may be useful in optimizing drug administration. |
format | Online Article Text |
id | pubmed-8954545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89545452022-03-26 Role of Pharmacogenetics in the Treatment of Acute Myeloid Leukemia: Systematic Review and Future Perspectives Pinto-Merino, Álvaro Labrador, Jorge Zubiaur, Pablo Alcaraz, Raquel Herrero, María José Montesinos, Pau Abad-Santos, Francisco Saiz-Rodríguez, Miriam Pharmaceutics Review Acute myeloid leukemia (AML) is a heterogeneous disease characterized by remarkable toxicity and great variability in response to treatment. Plenteous pharmacogenetic studies have already been published for classical therapies, such as cytarabine or anthracyclines, but such studies remain scarce for newer drugs. There is evidence of the relevance of polymorphisms in response to treatment, although most studies have limitations in terms of cohort size or standardization of results. The different responses associated with genetic variability include both increased drug efficacy and toxicity and decreased response or resistance to treatment. A broad pharmacogenetic understanding may be useful in the design of dosing strategies and treatment guidelines. The aim of this study is to perform a review of the available publications and evidence related to the pharmacogenetics of AML, compiling those studies that may be useful in optimizing drug administration. MDPI 2022-03-03 /pmc/articles/PMC8954545/ /pubmed/35335935 http://dx.doi.org/10.3390/pharmaceutics14030559 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pinto-Merino, Álvaro Labrador, Jorge Zubiaur, Pablo Alcaraz, Raquel Herrero, María José Montesinos, Pau Abad-Santos, Francisco Saiz-Rodríguez, Miriam Role of Pharmacogenetics in the Treatment of Acute Myeloid Leukemia: Systematic Review and Future Perspectives |
title | Role of Pharmacogenetics in the Treatment of Acute Myeloid Leukemia: Systematic Review and Future Perspectives |
title_full | Role of Pharmacogenetics in the Treatment of Acute Myeloid Leukemia: Systematic Review and Future Perspectives |
title_fullStr | Role of Pharmacogenetics in the Treatment of Acute Myeloid Leukemia: Systematic Review and Future Perspectives |
title_full_unstemmed | Role of Pharmacogenetics in the Treatment of Acute Myeloid Leukemia: Systematic Review and Future Perspectives |
title_short | Role of Pharmacogenetics in the Treatment of Acute Myeloid Leukemia: Systematic Review and Future Perspectives |
title_sort | role of pharmacogenetics in the treatment of acute myeloid leukemia: systematic review and future perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954545/ https://www.ncbi.nlm.nih.gov/pubmed/35335935 http://dx.doi.org/10.3390/pharmaceutics14030559 |
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