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Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021

On 28 April 2021, the investigation team of the Department of Disease Control, Ministry of Public Health, was notified of a cluster of people developing neurological symptoms following COVID-19 vaccination in a province in eastern Thailand. We conducted an investigation from 29 April to 20 May 2021...

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Autores principales: Mahasing, Chayanit, Yasopa, Oiythip, Sansilapin, Chalo, Rattanathumsakul, Thanit, Thammawijaya, Panithee, Suphanchaimat, Rapeepong, Doung-ngern, Pawinee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954559/
https://www.ncbi.nlm.nih.gov/pubmed/35335073
http://dx.doi.org/10.3390/vaccines10030441
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author Mahasing, Chayanit
Yasopa, Oiythip
Sansilapin, Chalo
Rattanathumsakul, Thanit
Thammawijaya, Panithee
Suphanchaimat, Rapeepong
Doung-ngern, Pawinee
author_facet Mahasing, Chayanit
Yasopa, Oiythip
Sansilapin, Chalo
Rattanathumsakul, Thanit
Thammawijaya, Panithee
Suphanchaimat, Rapeepong
Doung-ngern, Pawinee
author_sort Mahasing, Chayanit
collection PubMed
description On 28 April 2021, the investigation team of the Department of Disease Control, Ministry of Public Health, was notified of a cluster of people developing neurological symptoms following COVID-19 vaccination in a province in eastern Thailand. We conducted an investigation from 29 April to 20 May 2021 to confirm the outbreak, describe the epidemiological characteristics and identify possible risk factors. A matched case-control study was conducted. Matching factors were gender and vaccination site. A confirmed case was a person receiving COVID-19 vaccination in the province and developed at least one neurological symptom between 21 April and 20 May 2021. The rapid assessment of the vaccination cold chain system was carried out. We found a total of 36 cases out of 3920 vaccinees (attack rate = 0.92%), all cases were recovered and classified as an immunization stress-related reaction (ISRR) by the National AEFI Expert Committee. An analytic study found that menstruation was significantly associated with ISRR (AOR = 6.84 [95%CI = 1.09–42.91]). The environmental survey suggested that the cold chain system was properly managed. Further studies on other precipitating causes of ISRR should be performed. In terms of recommendation, health providers should pay greater attention to women menstruating during and after COVID-19 immunization.
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spelling pubmed-89545592022-03-26 Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021 Mahasing, Chayanit Yasopa, Oiythip Sansilapin, Chalo Rattanathumsakul, Thanit Thammawijaya, Panithee Suphanchaimat, Rapeepong Doung-ngern, Pawinee Vaccines (Basel) Article On 28 April 2021, the investigation team of the Department of Disease Control, Ministry of Public Health, was notified of a cluster of people developing neurological symptoms following COVID-19 vaccination in a province in eastern Thailand. We conducted an investigation from 29 April to 20 May 2021 to confirm the outbreak, describe the epidemiological characteristics and identify possible risk factors. A matched case-control study was conducted. Matching factors were gender and vaccination site. A confirmed case was a person receiving COVID-19 vaccination in the province and developed at least one neurological symptom between 21 April and 20 May 2021. The rapid assessment of the vaccination cold chain system was carried out. We found a total of 36 cases out of 3920 vaccinees (attack rate = 0.92%), all cases were recovered and classified as an immunization stress-related reaction (ISRR) by the National AEFI Expert Committee. An analytic study found that menstruation was significantly associated with ISRR (AOR = 6.84 [95%CI = 1.09–42.91]). The environmental survey suggested that the cold chain system was properly managed. Further studies on other precipitating causes of ISRR should be performed. In terms of recommendation, health providers should pay greater attention to women menstruating during and after COVID-19 immunization. MDPI 2022-03-14 /pmc/articles/PMC8954559/ /pubmed/35335073 http://dx.doi.org/10.3390/vaccines10030441 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mahasing, Chayanit
Yasopa, Oiythip
Sansilapin, Chalo
Rattanathumsakul, Thanit
Thammawijaya, Panithee
Suphanchaimat, Rapeepong
Doung-ngern, Pawinee
Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021
title Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021
title_full Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021
title_fullStr Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021
title_full_unstemmed Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021
title_short Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021
title_sort investigation of a cluster of immunization stress-related reactions after coronavirus disease 2019 (covid-19) vaccination, thailand, 2021
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954559/
https://www.ncbi.nlm.nih.gov/pubmed/35335073
http://dx.doi.org/10.3390/vaccines10030441
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