A Comparative Analysis of Weizmannia coagulans Genomes Unravels the Genetic Potential for Biotechnological Applications

The production of biochemicals requires the use of microbial strains with efficient substrate conversion and excellent environmental robustness, such as Weizmannia coagulans species. So far, the genomes of 47 strains have been sequenced. Herein, we report a comparative genomic analysis of nine strai...

Descripción completa

Detalles Bibliográficos
Autores principales: Aulitto, Martina, Martinez-Alvarez, Laura, Fiorentino, Gabriella, Limauro, Danila, Peng, Xu, Contursi, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954581/
https://www.ncbi.nlm.nih.gov/pubmed/35328559
http://dx.doi.org/10.3390/ijms23063135
_version_ 1784676128568377344
author Aulitto, Martina
Martinez-Alvarez, Laura
Fiorentino, Gabriella
Limauro, Danila
Peng, Xu
Contursi, Patrizia
author_facet Aulitto, Martina
Martinez-Alvarez, Laura
Fiorentino, Gabriella
Limauro, Danila
Peng, Xu
Contursi, Patrizia
author_sort Aulitto, Martina
collection PubMed
description The production of biochemicals requires the use of microbial strains with efficient substrate conversion and excellent environmental robustness, such as Weizmannia coagulans species. So far, the genomes of 47 strains have been sequenced. Herein, we report a comparative genomic analysis of nine strains on the full repertoire of Carbohydrate-Active enZymes (CAZymes), secretion systems, and resistance mechanisms to environmental challenges. Moreover, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) immune system along with CRISPR-associated (Cas) genes, was also analyzed. Overall, this study expands our understanding of the strain’s genomic diversity of W. coagulans to fully exploit its potential in biotechnological applications.
format Online
Article
Text
id pubmed-8954581
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89545812022-03-26 A Comparative Analysis of Weizmannia coagulans Genomes Unravels the Genetic Potential for Biotechnological Applications Aulitto, Martina Martinez-Alvarez, Laura Fiorentino, Gabriella Limauro, Danila Peng, Xu Contursi, Patrizia Int J Mol Sci Article The production of biochemicals requires the use of microbial strains with efficient substrate conversion and excellent environmental robustness, such as Weizmannia coagulans species. So far, the genomes of 47 strains have been sequenced. Herein, we report a comparative genomic analysis of nine strains on the full repertoire of Carbohydrate-Active enZymes (CAZymes), secretion systems, and resistance mechanisms to environmental challenges. Moreover, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) immune system along with CRISPR-associated (Cas) genes, was also analyzed. Overall, this study expands our understanding of the strain’s genomic diversity of W. coagulans to fully exploit its potential in biotechnological applications. MDPI 2022-03-15 /pmc/articles/PMC8954581/ /pubmed/35328559 http://dx.doi.org/10.3390/ijms23063135 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aulitto, Martina
Martinez-Alvarez, Laura
Fiorentino, Gabriella
Limauro, Danila
Peng, Xu
Contursi, Patrizia
A Comparative Analysis of Weizmannia coagulans Genomes Unravels the Genetic Potential for Biotechnological Applications
title A Comparative Analysis of Weizmannia coagulans Genomes Unravels the Genetic Potential for Biotechnological Applications
title_full A Comparative Analysis of Weizmannia coagulans Genomes Unravels the Genetic Potential for Biotechnological Applications
title_fullStr A Comparative Analysis of Weizmannia coagulans Genomes Unravels the Genetic Potential for Biotechnological Applications
title_full_unstemmed A Comparative Analysis of Weizmannia coagulans Genomes Unravels the Genetic Potential for Biotechnological Applications
title_short A Comparative Analysis of Weizmannia coagulans Genomes Unravels the Genetic Potential for Biotechnological Applications
title_sort comparative analysis of weizmannia coagulans genomes unravels the genetic potential for biotechnological applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954581/
https://www.ncbi.nlm.nih.gov/pubmed/35328559
http://dx.doi.org/10.3390/ijms23063135
work_keys_str_mv AT aulittomartina acomparativeanalysisofweizmanniacoagulansgenomesunravelsthegeneticpotentialforbiotechnologicalapplications
AT martinezalvarezlaura acomparativeanalysisofweizmanniacoagulansgenomesunravelsthegeneticpotentialforbiotechnologicalapplications
AT fiorentinogabriella acomparativeanalysisofweizmanniacoagulansgenomesunravelsthegeneticpotentialforbiotechnologicalapplications
AT limaurodanila acomparativeanalysisofweizmanniacoagulansgenomesunravelsthegeneticpotentialforbiotechnologicalapplications
AT pengxu acomparativeanalysisofweizmanniacoagulansgenomesunravelsthegeneticpotentialforbiotechnologicalapplications
AT contursipatrizia acomparativeanalysisofweizmanniacoagulansgenomesunravelsthegeneticpotentialforbiotechnologicalapplications
AT aulittomartina comparativeanalysisofweizmanniacoagulansgenomesunravelsthegeneticpotentialforbiotechnologicalapplications
AT martinezalvarezlaura comparativeanalysisofweizmanniacoagulansgenomesunravelsthegeneticpotentialforbiotechnologicalapplications
AT fiorentinogabriella comparativeanalysisofweizmanniacoagulansgenomesunravelsthegeneticpotentialforbiotechnologicalapplications
AT limaurodanila comparativeanalysisofweizmanniacoagulansgenomesunravelsthegeneticpotentialforbiotechnologicalapplications
AT pengxu comparativeanalysisofweizmanniacoagulansgenomesunravelsthegeneticpotentialforbiotechnologicalapplications
AT contursipatrizia comparativeanalysisofweizmanniacoagulansgenomesunravelsthegeneticpotentialforbiotechnologicalapplications

Ejemplares similares