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Fungal Allergen and Mold Allergy Diagnosis: Role and Relevance of Alternaria alternata Alt a 1 Protein Family

Alternaria is a genus of worldwide fungi found in different habitats such as soil, the atmosphere, plants or indoor environments. Alternaria species are saprobic—largely involved in the decomposition of organic material—but they can also act as animal pathogens, causing disease in humans and animals...

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Autores principales: Sánchez, Patricia, Vélez-del-Burgo, Ainara, Suñén, Ester, Martínez, Jorge, Postigo, Idoia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954643/
https://www.ncbi.nlm.nih.gov/pubmed/35330279
http://dx.doi.org/10.3390/jof8030277
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author Sánchez, Patricia
Vélez-del-Burgo, Ainara
Suñén, Ester
Martínez, Jorge
Postigo, Idoia
author_facet Sánchez, Patricia
Vélez-del-Burgo, Ainara
Suñén, Ester
Martínez, Jorge
Postigo, Idoia
author_sort Sánchez, Patricia
collection PubMed
description Alternaria is a genus of worldwide fungi found in different habitats such as soil, the atmosphere, plants or indoor environments. Alternaria species are saprobic—largely involved in the decomposition of organic material—but they can also act as animal pathogens, causing disease in humans and animals, developing infections, toxicosis and allergic diseases. A. alternata is considered one of the most important sources of fungal allergens worldwide and it is associated with severe asthma and respiratory status. Among the A. alternata allergens, Alt a 1 is the main sensitizing allergen and its usefulness in diagnosis and immunotherapy has been demonstrated. Alt a 1 seems to define a protein family that can be used to identify related pathogenic fungi in plants and fruits, and to establish taxonomic relationships between the different fungal divisions.
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spelling pubmed-89546432022-03-26 Fungal Allergen and Mold Allergy Diagnosis: Role and Relevance of Alternaria alternata Alt a 1 Protein Family Sánchez, Patricia Vélez-del-Burgo, Ainara Suñén, Ester Martínez, Jorge Postigo, Idoia J Fungi (Basel) Review Alternaria is a genus of worldwide fungi found in different habitats such as soil, the atmosphere, plants or indoor environments. Alternaria species are saprobic—largely involved in the decomposition of organic material—but they can also act as animal pathogens, causing disease in humans and animals, developing infections, toxicosis and allergic diseases. A. alternata is considered one of the most important sources of fungal allergens worldwide and it is associated with severe asthma and respiratory status. Among the A. alternata allergens, Alt a 1 is the main sensitizing allergen and its usefulness in diagnosis and immunotherapy has been demonstrated. Alt a 1 seems to define a protein family that can be used to identify related pathogenic fungi in plants and fruits, and to establish taxonomic relationships between the different fungal divisions. MDPI 2022-03-09 /pmc/articles/PMC8954643/ /pubmed/35330279 http://dx.doi.org/10.3390/jof8030277 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sánchez, Patricia
Vélez-del-Burgo, Ainara
Suñén, Ester
Martínez, Jorge
Postigo, Idoia
Fungal Allergen and Mold Allergy Diagnosis: Role and Relevance of Alternaria alternata Alt a 1 Protein Family
title Fungal Allergen and Mold Allergy Diagnosis: Role and Relevance of Alternaria alternata Alt a 1 Protein Family
title_full Fungal Allergen and Mold Allergy Diagnosis: Role and Relevance of Alternaria alternata Alt a 1 Protein Family
title_fullStr Fungal Allergen and Mold Allergy Diagnosis: Role and Relevance of Alternaria alternata Alt a 1 Protein Family
title_full_unstemmed Fungal Allergen and Mold Allergy Diagnosis: Role and Relevance of Alternaria alternata Alt a 1 Protein Family
title_short Fungal Allergen and Mold Allergy Diagnosis: Role and Relevance of Alternaria alternata Alt a 1 Protein Family
title_sort fungal allergen and mold allergy diagnosis: role and relevance of alternaria alternata alt a 1 protein family
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954643/
https://www.ncbi.nlm.nih.gov/pubmed/35330279
http://dx.doi.org/10.3390/jof8030277
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