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Pathophysiology of Atherosclerosis

Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and, followed by a cascade of events (accumulation of lipids, fibrous elements, and calcification), triggers the vessel...

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Autores principales: Jebari-Benslaiman, Shifa, Galicia-García, Unai, Larrea-Sebal, Asier, Olaetxea, Javier Rekondo, Alloza, Iraide, Vandenbroeck, Koen, Benito-Vicente, Asier, Martín, César
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954705/
https://www.ncbi.nlm.nih.gov/pubmed/35328769
http://dx.doi.org/10.3390/ijms23063346
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author Jebari-Benslaiman, Shifa
Galicia-García, Unai
Larrea-Sebal, Asier
Olaetxea, Javier Rekondo
Alloza, Iraide
Vandenbroeck, Koen
Benito-Vicente, Asier
Martín, César
author_facet Jebari-Benslaiman, Shifa
Galicia-García, Unai
Larrea-Sebal, Asier
Olaetxea, Javier Rekondo
Alloza, Iraide
Vandenbroeck, Koen
Benito-Vicente, Asier
Martín, César
author_sort Jebari-Benslaiman, Shifa
collection PubMed
description Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and, followed by a cascade of events (accumulation of lipids, fibrous elements, and calcification), triggers the vessel narrowing and activation of inflammatory pathways. The resultant atheroma plaque, along with these processes, results in cardiovascular complications. This review focuses on the different stages of atherosclerosis development, ranging from endothelial dysfunction to plaque rupture. In addition, the post-transcriptional regulation and modulation of atheroma plaque by microRNAs and lncRNAs, the role of microbiota, and the importance of sex as a crucial risk factor in atherosclerosis are covered here in order to provide a global view of the disease.
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spelling pubmed-89547052022-03-26 Pathophysiology of Atherosclerosis Jebari-Benslaiman, Shifa Galicia-García, Unai Larrea-Sebal, Asier Olaetxea, Javier Rekondo Alloza, Iraide Vandenbroeck, Koen Benito-Vicente, Asier Martín, César Int J Mol Sci Review Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and, followed by a cascade of events (accumulation of lipids, fibrous elements, and calcification), triggers the vessel narrowing and activation of inflammatory pathways. The resultant atheroma plaque, along with these processes, results in cardiovascular complications. This review focuses on the different stages of atherosclerosis development, ranging from endothelial dysfunction to plaque rupture. In addition, the post-transcriptional regulation and modulation of atheroma plaque by microRNAs and lncRNAs, the role of microbiota, and the importance of sex as a crucial risk factor in atherosclerosis are covered here in order to provide a global view of the disease. MDPI 2022-03-20 /pmc/articles/PMC8954705/ /pubmed/35328769 http://dx.doi.org/10.3390/ijms23063346 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jebari-Benslaiman, Shifa
Galicia-García, Unai
Larrea-Sebal, Asier
Olaetxea, Javier Rekondo
Alloza, Iraide
Vandenbroeck, Koen
Benito-Vicente, Asier
Martín, César
Pathophysiology of Atherosclerosis
title Pathophysiology of Atherosclerosis
title_full Pathophysiology of Atherosclerosis
title_fullStr Pathophysiology of Atherosclerosis
title_full_unstemmed Pathophysiology of Atherosclerosis
title_short Pathophysiology of Atherosclerosis
title_sort pathophysiology of atherosclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954705/
https://www.ncbi.nlm.nih.gov/pubmed/35328769
http://dx.doi.org/10.3390/ijms23063346
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