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Identification of Pharmacophoric Fragments of DYRK1A Inhibitors Using Machine Learning Classification Models

Dual-specific tyrosine phosphorylation regulated kinase 1 (DYRK1A) has been regarded as a potential therapeutic target of neurodegenerative diseases, and considerable progress has been made in the discovery of DYRK1A inhibitors. Identification of pharmacophoric fragments provides valuable informatio...

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Detalles Bibliográficos
Autores principales: Bi, Mengzhou, Guan, Zhen, Fan, Tengjiao, Zhang, Na, Wang, Jianhua, Sun, Guohui, Zhao, Lijiao, Zhong, Rugang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954712/
https://www.ncbi.nlm.nih.gov/pubmed/35335117
http://dx.doi.org/10.3390/molecules27061753

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