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Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization
Based on the study of recent scientific literature devoted to neovascularization and angiogenesis in malignant neoplasms, it was concluded that there are many publications on each of the problems of tumor angiogenesis and vascularization. The formation of blood vessels in a tumor and certain aspects...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954734/ https://www.ncbi.nlm.nih.gov/pubmed/35330327 http://dx.doi.org/10.3390/jpm12030327 |
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author | Maiborodin, Igor Mansurova, Alfija Chernyavskiy, Alexander Romanov, Alexander Voitcitctkii, Vladimir Kedrova, Anna Tarkhov, Alexander Chernyshova, Alena Krasil’nikov, Sergey |
author_facet | Maiborodin, Igor Mansurova, Alfija Chernyavskiy, Alexander Romanov, Alexander Voitcitctkii, Vladimir Kedrova, Anna Tarkhov, Alexander Chernyshova, Alena Krasil’nikov, Sergey |
author_sort | Maiborodin, Igor |
collection | PubMed |
description | Based on the study of recent scientific literature devoted to neovascularization and angiogenesis in malignant neoplasms, it was concluded that there are many publications on each of the problems of tumor angiogenesis and vascularization. The formation of blood vessels in a tumor and certain aspects of the prognostic value of the severity of vascularization in almost all forms of cancer are considered. Special attention is paid to the peculiarities of angiogenesis in tumors of the female reproductive system. A large number of vessels in the tumor often indicates a poor prognosis. The influence of various factors on the initiation of angiogenesis and the process itself, as well as the possibility of suppressing such signals to slow down the formation of blood vessels and thus the development of the tumor are widely studied. The results of pharmacological suppression of tumor vessel formation demonstrate a good clinical outcome but one accompanied by a large number of severe adverse side effects. Such a significant amount of studies on each of the problems of tumor vascularization indicates the increasing importance of this area of oncology. At the same time, only a very small number of works are devoted to the study of the differences in angiogenesis and number of vessels between different parts of the tumor, as well as between the primary tumor node and its metastases. The refinement of the results is still to be done. It was noted that the expression of proangiogenic factors in metastases is usually higher than in the source of metastasis, and the expression in lymphogenous metastases is higher than in hematogenous ones. |
format | Online Article Text |
id | pubmed-8954734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89547342022-03-26 Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization Maiborodin, Igor Mansurova, Alfija Chernyavskiy, Alexander Romanov, Alexander Voitcitctkii, Vladimir Kedrova, Anna Tarkhov, Alexander Chernyshova, Alena Krasil’nikov, Sergey J Pers Med Review Based on the study of recent scientific literature devoted to neovascularization and angiogenesis in malignant neoplasms, it was concluded that there are many publications on each of the problems of tumor angiogenesis and vascularization. The formation of blood vessels in a tumor and certain aspects of the prognostic value of the severity of vascularization in almost all forms of cancer are considered. Special attention is paid to the peculiarities of angiogenesis in tumors of the female reproductive system. A large number of vessels in the tumor often indicates a poor prognosis. The influence of various factors on the initiation of angiogenesis and the process itself, as well as the possibility of suppressing such signals to slow down the formation of blood vessels and thus the development of the tumor are widely studied. The results of pharmacological suppression of tumor vessel formation demonstrate a good clinical outcome but one accompanied by a large number of severe adverse side effects. Such a significant amount of studies on each of the problems of tumor vascularization indicates the increasing importance of this area of oncology. At the same time, only a very small number of works are devoted to the study of the differences in angiogenesis and number of vessels between different parts of the tumor, as well as between the primary tumor node and its metastases. The refinement of the results is still to be done. It was noted that the expression of proangiogenic factors in metastases is usually higher than in the source of metastasis, and the expression in lymphogenous metastases is higher than in hematogenous ones. MDPI 2022-02-22 /pmc/articles/PMC8954734/ /pubmed/35330327 http://dx.doi.org/10.3390/jpm12030327 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Maiborodin, Igor Mansurova, Alfija Chernyavskiy, Alexander Romanov, Alexander Voitcitctkii, Vladimir Kedrova, Anna Tarkhov, Alexander Chernyshova, Alena Krasil’nikov, Sergey Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization |
title | Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization |
title_full | Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization |
title_fullStr | Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization |
title_full_unstemmed | Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization |
title_short | Cancer Angiogenesis and Opportunity of Influence on Tumor by Changing Vascularization |
title_sort | cancer angiogenesis and opportunity of influence on tumor by changing vascularization |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954734/ https://www.ncbi.nlm.nih.gov/pubmed/35330327 http://dx.doi.org/10.3390/jpm12030327 |
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