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Development of an LC-MS/MS Method for ARV-110, a PROTAC Molecule, and Applications to Pharmacokinetic Studies

ARV-110, a novel proteolysis-targeting chimera (PROTAC), has been reported to show satisfactory safety and tolerability for prostate cancer therapy in phase I clinical trials. However, there is a lack of bioanalytical assays for ARV-110 determination in biological samples. In this study, we develope...

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Detalles Bibliográficos
Autores principales:	Nguyen, Thi-Thao-Linh, Kim, Jin Woo, Choi, Hae-In, Maeng, Han-Joo, Koo, Tae-Sung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954769/ https://www.ncbi.nlm.nih.gov/pubmed/35335338 http://dx.doi.org/10.3390/molecules27061977

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