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Precise Droplet Dispensing in Digital Microfluidics with Dumbbell-Shaped Electrodes
Electro-wetting-on-dielectric (EWOD) enables the manipulation of droplets on a two-dimensional surface, which provides a versatile technique for digital microfluidics at a micro- or nano-scale. However, the deficiency of the dispensing precision has long limited its applications in micro total analy...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954859/ https://www.ncbi.nlm.nih.gov/pubmed/35334775 http://dx.doi.org/10.3390/mi13030484 |
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author | Wang, Wei |
author_facet | Wang, Wei |
author_sort | Wang, Wei |
collection | PubMed |
description | Electro-wetting-on-dielectric (EWOD) enables the manipulation of droplets on a two-dimensional surface, which provides a versatile technique for digital microfluidics at a micro- or nano-scale. However, the deficiency of the dispensing precision has long limited its applications in micro total analysis systems (μ-TAS) where the accuracy of assays is largely determined by the volume control of the reagent dosing. This paper proposes optimum electrode designs and carries out characterization experiments to demonstrate the reproducibility of on-chip droplet generation with no extra external apparatus. The coefficient variation of the volumes of consecutively dispensed droplets from a non-refilling reservoir can be limited to below 0.3%, indicating the validity of the new electrode structure in practical applications. |
format | Online Article Text |
id | pubmed-8954859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89548592022-03-26 Precise Droplet Dispensing in Digital Microfluidics with Dumbbell-Shaped Electrodes Wang, Wei Micromachines (Basel) Article Electro-wetting-on-dielectric (EWOD) enables the manipulation of droplets on a two-dimensional surface, which provides a versatile technique for digital microfluidics at a micro- or nano-scale. However, the deficiency of the dispensing precision has long limited its applications in micro total analysis systems (μ-TAS) where the accuracy of assays is largely determined by the volume control of the reagent dosing. This paper proposes optimum electrode designs and carries out characterization experiments to demonstrate the reproducibility of on-chip droplet generation with no extra external apparatus. The coefficient variation of the volumes of consecutively dispensed droplets from a non-refilling reservoir can be limited to below 0.3%, indicating the validity of the new electrode structure in practical applications. MDPI 2022-03-20 /pmc/articles/PMC8954859/ /pubmed/35334775 http://dx.doi.org/10.3390/mi13030484 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Wei Precise Droplet Dispensing in Digital Microfluidics with Dumbbell-Shaped Electrodes |
title | Precise Droplet Dispensing in Digital Microfluidics with Dumbbell-Shaped Electrodes |
title_full | Precise Droplet Dispensing in Digital Microfluidics with Dumbbell-Shaped Electrodes |
title_fullStr | Precise Droplet Dispensing in Digital Microfluidics with Dumbbell-Shaped Electrodes |
title_full_unstemmed | Precise Droplet Dispensing in Digital Microfluidics with Dumbbell-Shaped Electrodes |
title_short | Precise Droplet Dispensing in Digital Microfluidics with Dumbbell-Shaped Electrodes |
title_sort | precise droplet dispensing in digital microfluidics with dumbbell-shaped electrodes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954859/ https://www.ncbi.nlm.nih.gov/pubmed/35334775 http://dx.doi.org/10.3390/mi13030484 |
work_keys_str_mv | AT wangwei precisedropletdispensingindigitalmicrofluidicswithdumbbellshapedelectrodes |