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Long‐term response to crizotinib in a 17‐year‐old boy with treatment‐naïve ALK‐positive non‐small‐cell lung cancer
BACKGROUND: Lung cancer is the leading cause of cancer‐related death. NSCLC accounts for 80–90% of cases. In young patients, adenocarcinoma is the most frequent histotype and 3–7% expresses the rearrangement of ALK oncogene, sensitive to TKIs. Crizotinib is the first ALK inhibitor approved by the FD...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955048/ https://www.ncbi.nlm.nih.gov/pubmed/35092185 http://dx.doi.org/10.1002/cnr2.1483 |
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author | Megaro, Giacomina Miele, Evelina Spinelli, Gian Paolo Alessi, Iside Del Baldo, Giada Cozza, Raffaele Russo, Ida De Pasquale, Maria Debora Cefalo, Maria Giuseppina Tomà, Paolo Carai, Andrea Di Ruscio, Valentina De Ioris, Maria Antonietta Mastronuzzi, Angela |
author_facet | Megaro, Giacomina Miele, Evelina Spinelli, Gian Paolo Alessi, Iside Del Baldo, Giada Cozza, Raffaele Russo, Ida De Pasquale, Maria Debora Cefalo, Maria Giuseppina Tomà, Paolo Carai, Andrea Di Ruscio, Valentina De Ioris, Maria Antonietta Mastronuzzi, Angela |
author_sort | Megaro, Giacomina |
collection | PubMed |
description | BACKGROUND: Lung cancer is the leading cause of cancer‐related death. NSCLC accounts for 80–90% of cases. In young patients, adenocarcinoma is the most frequent histotype and 3–7% expresses the rearrangement of ALK oncogene, sensitive to TKIs. Crizotinib is the first ALK inhibitor approved by the FDA. CASE: We present a case of a 17‐year‐old male with metastatic treatment‐naïve ALK‐positive adenocarcinoma. He was treated with crizotinib and obtained a prolonged response with PFS of 33 months. CONCLUSION: Crizotinib can be extremely effective in adolescents with treatment‐naïve ALK‐positive NSCLC but fail to prevent a central nervous system relapse. Resistance mechanisms need to be investigated. |
format | Online Article Text |
id | pubmed-8955048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89550482022-03-29 Long‐term response to crizotinib in a 17‐year‐old boy with treatment‐naïve ALK‐positive non‐small‐cell lung cancer Megaro, Giacomina Miele, Evelina Spinelli, Gian Paolo Alessi, Iside Del Baldo, Giada Cozza, Raffaele Russo, Ida De Pasquale, Maria Debora Cefalo, Maria Giuseppina Tomà, Paolo Carai, Andrea Di Ruscio, Valentina De Ioris, Maria Antonietta Mastronuzzi, Angela Cancer Rep (Hoboken) Case Report BACKGROUND: Lung cancer is the leading cause of cancer‐related death. NSCLC accounts for 80–90% of cases. In young patients, adenocarcinoma is the most frequent histotype and 3–7% expresses the rearrangement of ALK oncogene, sensitive to TKIs. Crizotinib is the first ALK inhibitor approved by the FDA. CASE: We present a case of a 17‐year‐old male with metastatic treatment‐naïve ALK‐positive adenocarcinoma. He was treated with crizotinib and obtained a prolonged response with PFS of 33 months. CONCLUSION: Crizotinib can be extremely effective in adolescents with treatment‐naïve ALK‐positive NSCLC but fail to prevent a central nervous system relapse. Resistance mechanisms need to be investigated. John Wiley and Sons Inc. 2022-01-28 /pmc/articles/PMC8955048/ /pubmed/35092185 http://dx.doi.org/10.1002/cnr2.1483 Text en © 2022 The Authors. Cancer Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Megaro, Giacomina Miele, Evelina Spinelli, Gian Paolo Alessi, Iside Del Baldo, Giada Cozza, Raffaele Russo, Ida De Pasquale, Maria Debora Cefalo, Maria Giuseppina Tomà, Paolo Carai, Andrea Di Ruscio, Valentina De Ioris, Maria Antonietta Mastronuzzi, Angela Long‐term response to crizotinib in a 17‐year‐old boy with treatment‐naïve ALK‐positive non‐small‐cell lung cancer |
title | Long‐term response to crizotinib in a 17‐year‐old boy with treatment‐naïve ALK‐positive non‐small‐cell lung cancer |
title_full | Long‐term response to crizotinib in a 17‐year‐old boy with treatment‐naïve ALK‐positive non‐small‐cell lung cancer |
title_fullStr | Long‐term response to crizotinib in a 17‐year‐old boy with treatment‐naïve ALK‐positive non‐small‐cell lung cancer |
title_full_unstemmed | Long‐term response to crizotinib in a 17‐year‐old boy with treatment‐naïve ALK‐positive non‐small‐cell lung cancer |
title_short | Long‐term response to crizotinib in a 17‐year‐old boy with treatment‐naïve ALK‐positive non‐small‐cell lung cancer |
title_sort | long‐term response to crizotinib in a 17‐year‐old boy with treatment‐naïve alk‐positive non‐small‐cell lung cancer |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955048/ https://www.ncbi.nlm.nih.gov/pubmed/35092185 http://dx.doi.org/10.1002/cnr2.1483 |
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