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Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020

There is a growing interest in echovirus 30 (E30), an enterovirus responsible for neurological disease and hospitalization. There are multiple studies of outbreaks, but few that study the epidemiology over long periods of time. Our study aims to describe the clinical, epidemiological and microbiolog...

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Autores principales: del Cuerpo, Margarita, Gonzalez de Audicana, Jon, Fernandez-Garcia, Maria Dolores, Marín, Pilar, Esteban, Montserrat, Español, Montserrat, Cabrerizo, María, Rabella, Núria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955149/
https://www.ncbi.nlm.nih.gov/pubmed/35336167
http://dx.doi.org/10.3390/microorganisms10030592
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author del Cuerpo, Margarita
Gonzalez de Audicana, Jon
Fernandez-Garcia, Maria Dolores
Marín, Pilar
Esteban, Montserrat
Español, Montserrat
Cabrerizo, María
Rabella, Núria
author_facet del Cuerpo, Margarita
Gonzalez de Audicana, Jon
Fernandez-Garcia, Maria Dolores
Marín, Pilar
Esteban, Montserrat
Español, Montserrat
Cabrerizo, María
Rabella, Núria
author_sort del Cuerpo, Margarita
collection PubMed
description There is a growing interest in echovirus 30 (E30), an enterovirus responsible for neurological disease and hospitalization. There are multiple studies of outbreaks, but few that study the epidemiology over long periods of time. Our study aims to describe the clinical, epidemiological and microbiological characteristics of a series of E30 infections detected over 26 years. Data were retrospectively collected from a database of all enterovirus infections identified in our laboratory. They were detected by viral isolation or nucleic acid detection in patients presenting with respiratory or neurological infections, rash, sepsis-like syndrome, or gastroenteritis. Enterovirus genotyping was performed by amplification of the VP1 gene using RT-nested PCR, followed by sequencing and BLAST analysis. Of the 2402 enterovirus infections detected, 1619 were linked to at least one genotype and 173 were caused by E30. Clinical information was available for 158 (91.3%) patients. E30 was associated with neurological infection in 107 (67.8%) cases and it was detected almost every year. Phylogenetic analysis was performed with 67 sequences. We observed that E30 strains circulating in Catalonia from 1996 to 2016 belong to two lineages (E and F), although the majority cluster was in F. In 2018, lineage I emerged as the dominant lineage.
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spelling pubmed-89551492022-03-26 Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020 del Cuerpo, Margarita Gonzalez de Audicana, Jon Fernandez-Garcia, Maria Dolores Marín, Pilar Esteban, Montserrat Español, Montserrat Cabrerizo, María Rabella, Núria Microorganisms Article There is a growing interest in echovirus 30 (E30), an enterovirus responsible for neurological disease and hospitalization. There are multiple studies of outbreaks, but few that study the epidemiology over long periods of time. Our study aims to describe the clinical, epidemiological and microbiological characteristics of a series of E30 infections detected over 26 years. Data were retrospectively collected from a database of all enterovirus infections identified in our laboratory. They were detected by viral isolation or nucleic acid detection in patients presenting with respiratory or neurological infections, rash, sepsis-like syndrome, or gastroenteritis. Enterovirus genotyping was performed by amplification of the VP1 gene using RT-nested PCR, followed by sequencing and BLAST analysis. Of the 2402 enterovirus infections detected, 1619 were linked to at least one genotype and 173 were caused by E30. Clinical information was available for 158 (91.3%) patients. E30 was associated with neurological infection in 107 (67.8%) cases and it was detected almost every year. Phylogenetic analysis was performed with 67 sequences. We observed that E30 strains circulating in Catalonia from 1996 to 2016 belong to two lineages (E and F), although the majority cluster was in F. In 2018, lineage I emerged as the dominant lineage. MDPI 2022-03-09 /pmc/articles/PMC8955149/ /pubmed/35336167 http://dx.doi.org/10.3390/microorganisms10030592 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
del Cuerpo, Margarita
Gonzalez de Audicana, Jon
Fernandez-Garcia, Maria Dolores
Marín, Pilar
Esteban, Montserrat
Español, Montserrat
Cabrerizo, María
Rabella, Núria
Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020
title Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020
title_full Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020
title_fullStr Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020
title_full_unstemmed Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020
title_short Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020
title_sort epidemiology of echovirus 30 infections detected in a university hospital in catalonia, spain, in 1995–2020
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955149/
https://www.ncbi.nlm.nih.gov/pubmed/35336167
http://dx.doi.org/10.3390/microorganisms10030592
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