Microvasculopathy-Related Hemorrhagic Tissue Deposition of Iron May Contribute to Fibrosis in Systemic Sclerosis: Hypothesis-Generating Insights from the Literature and Preliminary Findings

Microvascular wall abnormalities demonstrated by nailfold capillaroscopy in systemic sclerosis (SSc) may result in microhemorrhagic deposition of erythrocyte-derived iron. Such abnormalities precede fibrosis, which is orchestrated by myofibroblasts. Iron induces endothelial-to-mesenchymal transition...

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Detalles Bibliográficos
Autores principales: Sfikakis, Petros P., Vlachogiannis, Nikolaos I., Ntouros, Panagiotis A., Mavrogeni, Sophie, Maris, Thomas G., Karantanas, Apostolos H., Souliotis, Vassilis L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955192/
https://www.ncbi.nlm.nih.gov/pubmed/35330181
http://dx.doi.org/10.3390/life12030430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955192/
https://www.ncbi.nlm.nih.gov/pubmed/35330181
http://dx.doi.org/10.3390/life12030430

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