Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression

Animal models recapitulating COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Intranasally inoculated transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) represent a lethal model of SARS-CoV-2 infection. We eval...

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Detalles Bibliográficos
Autores principales: Carossino, Mariano, Kenney, Devin, O’Connell, Aoife K., Montanaro, Paige, Tseng, Anna E., Gertje, Hans P., Grosz, Kyle A., Ericsson, Maria, Huber, Bertrand R., Kurnick, Susanna A., Subramaniam, Saravanan, Kirkland, Thomas A., Walker, Joel R., Francis, Kevin P., Klose, Alexander D., Paragas, Neal, Bosmann, Markus, Saeed, Mohsan, Balasuriya, Udeni B. R., Douam, Florian, Crossland, Nicholas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955233/
https://www.ncbi.nlm.nih.gov/pubmed/35336942
http://dx.doi.org/10.3390/v14030535

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