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Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas

In humans, glioblastoma is the most prevalent primary malignant brain tumor. Usually, glioblastoma has specific characteristics, such as aggressive cell proliferation and rapid invasion of surrounding brain tissue, leading to a poor patient prognosis. The current therapy—which provides a multidiscip...

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Autores principales: Persano, Francesca, Gigli, Giuseppe, Leporatti, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955269/
https://www.ncbi.nlm.nih.gov/pubmed/35328780
http://dx.doi.org/10.3390/ijms23063360
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author Persano, Francesca
Gigli, Giuseppe
Leporatti, Stefano
author_facet Persano, Francesca
Gigli, Giuseppe
Leporatti, Stefano
author_sort Persano, Francesca
collection PubMed
description In humans, glioblastoma is the most prevalent primary malignant brain tumor. Usually, glioblastoma has specific characteristics, such as aggressive cell proliferation and rapid invasion of surrounding brain tissue, leading to a poor patient prognosis. The current therapy—which provides a multidisciplinary approach with surgery followed by radiotherapy and chemotherapy with temozolomide—is not very efficient since it faces clinical challenges such as tumor heterogeneity, invasiveness, and chemoresistance. In this respect, natural substances in the diet, integral components in the lifestyle medicine approach, can be seen as potential chemotherapeutics. There are several epidemiological studies that have shown the chemopreventive role of natural dietary compounds in cancer progression and development. These heterogeneous compounds can produce anti-glioblastoma effects through upregulation of apoptosis and autophagy; allowing the promotion of cell cycle arrest; interfering with tumor metabolism; and permitting proliferation, neuroinflammation, chemoresistance, angiogenesis, and metastasis inhibition. Although these beneficial effects are promising, the efficacy of natural compounds in glioblastoma is limited due to their bioavailability and blood–brain barrier permeability. Thereby, further clinical trials are necessary to confirm the in vitro and in vivo anticancer properties of natural compounds. In this article, we overview the role of several natural substances in the treatment of glioblastoma by considering the challenges to be overcome and future prospects.
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spelling pubmed-89552692022-03-26 Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas Persano, Francesca Gigli, Giuseppe Leporatti, Stefano Int J Mol Sci Review In humans, glioblastoma is the most prevalent primary malignant brain tumor. Usually, glioblastoma has specific characteristics, such as aggressive cell proliferation and rapid invasion of surrounding brain tissue, leading to a poor patient prognosis. The current therapy—which provides a multidisciplinary approach with surgery followed by radiotherapy and chemotherapy with temozolomide—is not very efficient since it faces clinical challenges such as tumor heterogeneity, invasiveness, and chemoresistance. In this respect, natural substances in the diet, integral components in the lifestyle medicine approach, can be seen as potential chemotherapeutics. There are several epidemiological studies that have shown the chemopreventive role of natural dietary compounds in cancer progression and development. These heterogeneous compounds can produce anti-glioblastoma effects through upregulation of apoptosis and autophagy; allowing the promotion of cell cycle arrest; interfering with tumor metabolism; and permitting proliferation, neuroinflammation, chemoresistance, angiogenesis, and metastasis inhibition. Although these beneficial effects are promising, the efficacy of natural compounds in glioblastoma is limited due to their bioavailability and blood–brain barrier permeability. Thereby, further clinical trials are necessary to confirm the in vitro and in vivo anticancer properties of natural compounds. In this article, we overview the role of several natural substances in the treatment of glioblastoma by considering the challenges to be overcome and future prospects. MDPI 2022-03-20 /pmc/articles/PMC8955269/ /pubmed/35328780 http://dx.doi.org/10.3390/ijms23063360 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Persano, Francesca
Gigli, Giuseppe
Leporatti, Stefano
Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas
title Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas
title_full Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas
title_fullStr Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas
title_full_unstemmed Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas
title_short Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas
title_sort natural compounds as promising adjuvant agents in the treatment of gliomas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955269/
https://www.ncbi.nlm.nih.gov/pubmed/35328780
http://dx.doi.org/10.3390/ijms23063360
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