Cargando…

Pioglitazone Synthetic Analogue Ameliorates Streptozotocin-Induced Diabetes Mellitus through Modulation of ACE 2/Angiotensin 1–7 via PI3K/AKT/mTOR Signaling Pathway

The renin angiotensin aldosterone system has a localized key regulatory action, especially in liver and body circulation. Furthermore, it accomplishes a significant role in the downregulation of the PI3K/AKT/mTOR signaling pathway that is involved in type II diabetes mellitus pathogenesis. The curre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahmed, Yasmin M., Abdelgawad, Mohamed A., Shalaby, Khaled, Ghoneim, Mohammed M., AboulMagd, Asmaa M., Abdelwahab, Nada S., Hassan, Hossam M., Othman, Asmaa M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955304/ https://www.ncbi.nlm.nih.gov/pubmed/35337139 http://dx.doi.org/10.3390/ph15030341

Ejemplares similares

Partial Synthetic PPARƳ Derivative Ameliorates Aorta Injury in Experimental Diabetic Rats Mediated by Activation of miR-126-5p Pi3k/AKT/PDK 1/mTOR Expression
por: Ahmed, Yasmin M., et al.
Publicado: (2022)

Ecological HPLC method for analyzing an antidiabetic drug in real rat plasma samples and studying the effects of concurrently administered fenugreek extract on its pharmacokinetics
por: Abdelwahab, Nada S., et al.
Publicado: (2021)

Saccharomonosporine A inspiration; synthesis of potent analogues as potential PIM kinase inhibitors
por: AboulMagd, Asmaa M., et al.
Publicado: (2020)

Ligand-based design, molecular dynamics and ADMET studies of suggested SARS-CoV-2 M(pro) inhibitors
por: Mohamed, Nada M., et al.
Publicado: (2021)

Development and Greenness Assessment of HPLC Method for Studying the Pharmacokinetics of Co-Administered Metformin and Papaya Extract
por: Abdelgawad, Mohamed A., et al.
Publicado: (2022)

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
por: Mansour, Mostafa A., et al.
Publicado: (2020)

Garcinia cambogia Phenolics as Potent Anti-COVID-19 Agents: Phytochemical Profiling, Biological Activities, and Molecular Docking
por: Aati, Hanan Y., et al.
Publicado: (2022)

Design, synthesis and mechanistic study of new benzenesulfonamide derivatives as anticancer and antimicrobial agents via carbonic anhydrase IX inhibition
por: Nemr, Mohamed T. M., et al.
Publicado: (2021)

Pyrrolizine/indolizine-bearing (un)substituted isoindole moiety: design, synthesis, antiproliferative and MDR reversal activities, and in silico studies
por: AbdelSamad, Amr L., et al.
Publicado: (2023)

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
por: Sayed, Ahmed M., et al.
Publicado: (2020)

Insights into fourth generation selective inhibitors of (C797S) EGFR mutation combating non-small cell lung cancer resistance: a critical review
por: Mansour, Mostafa A., et al.
Publicado: (2023)

Correction: Triple-negative breast cancer suppressive activities, antioxidants and pharmacophore model of new acylated rhamnopyranoses from Premna odorata
por: Elmaidomy, Abeer H., et al.
Publicado: (2021)

Bioassay-Guided Isolation, Metabolic Profiling, and Docking Studies of Hyaluronidase Inhibitors from Ravenala madagascariensis
por: M. Mohamed, Esraa, et al.
Publicado: (2020)

Antiulcer secondary metabolites from Elaeocarpus grandis, family Elaeocarpaceae, supported by in silico studies
por: Mohie El-Dien, Radwa Taher, et al.
Publicado: (2020)

Triple-negative breast cancer suppressive activities, antioxidants and pharmacophore model of new acylated rhamnopyranoses from Premna odorata
por: Elmaidomy, Abeer H., et al.
Publicado: (2020)

Metabolomic profiling, biological evaluation of Aspergillus awamori, the river Nile-derived fungus using epigenetic and OSMAC approaches
por: Lotfy, Momen M., et al.
Publicado: (2021)

Testicular Caspase-3 and β-Catenin Regulators Predicted via Comparative Metabolomics and Docking Studies
por: Hifnawy, Mohammed S., et al.
Publicado: (2020)

Chemical composition and protective role of Pulicaria undulata (L.) C.A. Mey. subsp. undulata against gastric ulcer induced by ethanol in rats
por: Fahmi, Abdelgawad A., et al.
Publicado: (2019)

The Effect of Pioglitazone on Antioxidant Levels and Renal Histopathology in Streptozotocin-Induced Diabetic Rats
por: Kuru Karabas, Munire, et al.
Publicado: (2013)

Effectiveness of Lifestyle Modification on Health-Related Quality of Life among Women with Polycystic Ovary Syndrome
por: Abobakr Ibrahim, Asmaa, et al.
Publicado: (2023)

Pioglitazone Ameliorates Hippocampal Neurodegeneration, Disturbances in Glucose Metabolism and AKT/mTOR Signaling Pathways in Pentyelenetetrazole-Kindled Mice
por: El-Megiri, Nada, et al.
Publicado: (2022)

Correction to: Vitamin D regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin‑induced diabetes
por: Fathi, Fatima El Zahra M., et al.
Publicado: (2022)

Omega-3 fatty acid-based self-microemulsifying drug delivery system (SMEDDS) of pioglitazone: Optimization, in vitro and in vivo studies
por: Emad, Nasr A., et al.
Publicado: (2023)

Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition
por: Elmeligie, Salwa, et al.
Publicado: (2019)

New Cytotoxic Cerebrosides from the Red Sea Cucumber Holothuria spinifera Supported by In-Silico Studies
por: Abdelhameed, Reda F. A., et al.
Publicado: (2020)

Efficiency of Bone Marrow-Derived Mesenchymal Stem Cells and Hesperetin in the Treatment of Streptozotocin-Induced Type 1 Diabetes in Wistar Rats
por: Ahmed, Osama M., et al.
Publicado: (2023)

ACE2: Angiotensin II/Angiotensin-(1–7) Balance in Cardiac and Renal Injury
por: Varagic, Jasmina, et al.
Publicado: (2014)

Pioglitazone Improves Potassium Channel Remodeling Induced by Angiotensin II in Atrial Myocytes
por: Gu, Jun, et al.
Publicado: (2014)

Aspirin potentiates blood glucose lowering effect of glimepiride-pioglitazone combination in streptozotocin-induced diabetic rats
por: Bag, Soumita, et al.
Publicado: (2014)

Synergism effects of pioglitazone and Urtica dioica extract in streptozotocin-induced nephropathy via attenuation of oxidative stress
por: Shokrzadeh, Mohammad, et al.
Publicado: (2017)

Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients
por: Osman, Ikram Omar, et al.
Publicado: (2021)

Elicitation of Phenolics from the Micropropagated Endangered Medicinal Plant Calligonum polygonoides L. (Polygonoaceae)
por: Owis, Asmaa I., et al.
Publicado: (2016)

Thalassosterol, a New Cytotoxic Aromatase Inhibitor Ergosterol Derivative from the Red Sea Seagrass Thalassodendron ciliatum
por: Abdelhameed, Reda F. A., et al.
Publicado: (2020)

Holospiniferoside: A New Antitumor Cerebroside from The Red Sea Cucumber Holothuria spinifera: In Vitro and In Silico Studies
por: Eltamany, Enas E., et al.
Publicado: (2021)

Conformational Properties of Seven Toac-Labeled Angiotensin I Analogues Correlate with Their Muscle Contraction Activity and Their Ability to Act as ACE Substrates
por: Teixeira, Luis Gustavo D., et al.
Publicado: (2015)

Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome
por: Gómez, Juan, et al.
Publicado: (2020)

ACE2, a new regulator of the renin–angiotensin system
por: Burrell, Louise M., et al.
Publicado: (2004)

Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE
por: Rella, Monika, et al.
Publicado: (2007)

Angiotensin Converting Enzyme (ACE) and ACE2 Bind Integrins and ACE2 Regulates Integrin Signalling
por: Clarke, Nicola E., et al.
Publicado: (2012)

ACE2 – From the renin–angiotensin system to gut microbiota and malnutrition
por: Perlot, Thomas, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_rp8aiu7mmjetenod7cq2u559u4