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Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites
Jacaranones are a small group of specific plant metabolites with promising biological activities. The occurrence of jacaranones is limited to only a few plant families, with Asteraceae being the most abundant source of these compounds. Therefore, jacaranones can also serve as chemotaxonomic markers....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955310/ https://www.ncbi.nlm.nih.gov/pubmed/35336664 http://dx.doi.org/10.3390/plants11060782 |
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author | Dávid, Csilla Zsuzsanna Kúsz, Norbert Pinke, Gyula Kulmány, Ágnes Zupkó, István Hohmann, Judit Vasas, Andrea |
author_facet | Dávid, Csilla Zsuzsanna Kúsz, Norbert Pinke, Gyula Kulmány, Ágnes Zupkó, István Hohmann, Judit Vasas, Andrea |
author_sort | Dávid, Csilla Zsuzsanna |
collection | PubMed |
description | Jacaranones are a small group of specific plant metabolites with promising biological activities. The occurrence of jacaranones is limited to only a few plant families, with Asteraceae being the most abundant source of these compounds. Therefore, jacaranones can also serve as chemotaxonomic markers. Our phytochemical investigation of Crepis pulchra L. (Asteraceae) resulted in three jacaranone derivatives (jacaranone, 2,3-dihydro-2-hydroxyjacaranone, 2,3-dihydro-2-methoxyjacaranone), and (6R,9S)-3-oxo-α-ionol-β-d-glucopyranoside, fulgidic acid, 12,15-octadecadienoic acid methyl ester, scopoletin and apigenin-7-O-β-d-glucoside. This is the first report on the isolation of jacaranones from a species belonging to the Cichorioideae subfamily of Asteraceae. Jacaranone derivatives were subjected to an in vitro antiproliferative assay against a panel of human cancer cell lines (MCF-7, MDA-MB-231, HeLa, and C33A), revealing high or moderate activities, with IC(50) values ranging from 6.3 to 26.5 μM. |
format | Online Article Text |
id | pubmed-8955310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89553102022-03-26 Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites Dávid, Csilla Zsuzsanna Kúsz, Norbert Pinke, Gyula Kulmány, Ágnes Zupkó, István Hohmann, Judit Vasas, Andrea Plants (Basel) Article Jacaranones are a small group of specific plant metabolites with promising biological activities. The occurrence of jacaranones is limited to only a few plant families, with Asteraceae being the most abundant source of these compounds. Therefore, jacaranones can also serve as chemotaxonomic markers. Our phytochemical investigation of Crepis pulchra L. (Asteraceae) resulted in three jacaranone derivatives (jacaranone, 2,3-dihydro-2-hydroxyjacaranone, 2,3-dihydro-2-methoxyjacaranone), and (6R,9S)-3-oxo-α-ionol-β-d-glucopyranoside, fulgidic acid, 12,15-octadecadienoic acid methyl ester, scopoletin and apigenin-7-O-β-d-glucoside. This is the first report on the isolation of jacaranones from a species belonging to the Cichorioideae subfamily of Asteraceae. Jacaranone derivatives were subjected to an in vitro antiproliferative assay against a panel of human cancer cell lines (MCF-7, MDA-MB-231, HeLa, and C33A), revealing high or moderate activities, with IC(50) values ranging from 6.3 to 26.5 μM. MDPI 2022-03-16 /pmc/articles/PMC8955310/ /pubmed/35336664 http://dx.doi.org/10.3390/plants11060782 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dávid, Csilla Zsuzsanna Kúsz, Norbert Pinke, Gyula Kulmány, Ágnes Zupkó, István Hohmann, Judit Vasas, Andrea Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites |
title | Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites |
title_full | Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites |
title_fullStr | Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites |
title_full_unstemmed | Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites |
title_short | Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites |
title_sort | jacaranone derivatives with antiproliferative activity from crepis pulchra and relevance of this group of plant metabolites |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955310/ https://www.ncbi.nlm.nih.gov/pubmed/35336664 http://dx.doi.org/10.3390/plants11060782 |
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