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Effect of Protocatechuic Acid Ethyl Ester on Biomembrane Models: Multilamellar Vesicles and Monolayers

The interactions of drugs with cell membranes are of primary importance for several processes involved in drugs activity. However, these interactions are very difficult to study due to the complexity of biological membranes. Lipid model membranes have been developed and used to gain insight into dru...

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Autores principales: Torrisi, Cristina, Malfa, Giuseppe Antonio, Acquaviva, Rosaria, Castelli, Francesco, Sarpietro, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955320/
https://www.ncbi.nlm.nih.gov/pubmed/35323757
http://dx.doi.org/10.3390/membranes12030283
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author Torrisi, Cristina
Malfa, Giuseppe Antonio
Acquaviva, Rosaria
Castelli, Francesco
Sarpietro, Maria Grazia
author_facet Torrisi, Cristina
Malfa, Giuseppe Antonio
Acquaviva, Rosaria
Castelli, Francesco
Sarpietro, Maria Grazia
author_sort Torrisi, Cristina
collection PubMed
description The interactions of drugs with cell membranes are of primary importance for several processes involved in drugs activity. However, these interactions are very difficult to study due to the complexity of biological membranes. Lipid model membranes have been developed and used to gain insight into drug–membrane interactions. In this study, the interaction of protocatechuic acid ethyl ester, showing radical-scavenging activity, antimicrobial, antitumor and anti-inflammatory effects, with model membranes constituted by multilamellar vesicles and monolayers made of DMPC and DSPC, has been studied. Differential scanning calorimetry and Langmuir–Blodgett techniques have been used. Protocatechuic acid ethyl ester interacted both with MLV and monolayers. However, a stronger interaction of the drug with DMPC-based model membranes has been obtained. The finding of this study could help to understand the protocatechuic acid ethyl ester action mechanism.
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spelling pubmed-89553202022-03-26 Effect of Protocatechuic Acid Ethyl Ester on Biomembrane Models: Multilamellar Vesicles and Monolayers Torrisi, Cristina Malfa, Giuseppe Antonio Acquaviva, Rosaria Castelli, Francesco Sarpietro, Maria Grazia Membranes (Basel) Article The interactions of drugs with cell membranes are of primary importance for several processes involved in drugs activity. However, these interactions are very difficult to study due to the complexity of biological membranes. Lipid model membranes have been developed and used to gain insight into drug–membrane interactions. In this study, the interaction of protocatechuic acid ethyl ester, showing radical-scavenging activity, antimicrobial, antitumor and anti-inflammatory effects, with model membranes constituted by multilamellar vesicles and monolayers made of DMPC and DSPC, has been studied. Differential scanning calorimetry and Langmuir–Blodgett techniques have been used. Protocatechuic acid ethyl ester interacted both with MLV and monolayers. However, a stronger interaction of the drug with DMPC-based model membranes has been obtained. The finding of this study could help to understand the protocatechuic acid ethyl ester action mechanism. MDPI 2022-02-28 /pmc/articles/PMC8955320/ /pubmed/35323757 http://dx.doi.org/10.3390/membranes12030283 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Torrisi, Cristina
Malfa, Giuseppe Antonio
Acquaviva, Rosaria
Castelli, Francesco
Sarpietro, Maria Grazia
Effect of Protocatechuic Acid Ethyl Ester on Biomembrane Models: Multilamellar Vesicles and Monolayers
title Effect of Protocatechuic Acid Ethyl Ester on Biomembrane Models: Multilamellar Vesicles and Monolayers
title_full Effect of Protocatechuic Acid Ethyl Ester on Biomembrane Models: Multilamellar Vesicles and Monolayers
title_fullStr Effect of Protocatechuic Acid Ethyl Ester on Biomembrane Models: Multilamellar Vesicles and Monolayers
title_full_unstemmed Effect of Protocatechuic Acid Ethyl Ester on Biomembrane Models: Multilamellar Vesicles and Monolayers
title_short Effect of Protocatechuic Acid Ethyl Ester on Biomembrane Models: Multilamellar Vesicles and Monolayers
title_sort effect of protocatechuic acid ethyl ester on biomembrane models: multilamellar vesicles and monolayers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955320/
https://www.ncbi.nlm.nih.gov/pubmed/35323757
http://dx.doi.org/10.3390/membranes12030283
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