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Factors Influencing Level and Persistence of Anti SARS-CoV-2 IgG after BNT162b2 Vaccine: Evidence from a Large Cohort of Healthcare Workers

We aimed at evaluating quantitative IgG response to BNT162b2 COVID-19 vaccine among health care workers (HCW), and exploring the role of demographic, clinical, and occupational factors as predictors of IgG levels. On May 2021, among 6687 HCW at the largest tertiary care University-Hospital of Northw...

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Autores principales: Costa, Cristina, Migliore, Enrica, Galassi, Claudia, Scozzari, Gitana, Ciccone, Giovannino, Coggiola, Maurizio, Pira, Enrico, Scarmozzino, Antonio, La Valle, Giovanni, Cassoni, Paola, Cavallo, Rossana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955419/
https://www.ncbi.nlm.nih.gov/pubmed/35335105
http://dx.doi.org/10.3390/vaccines10030474
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author Costa, Cristina
Migliore, Enrica
Galassi, Claudia
Scozzari, Gitana
Ciccone, Giovannino
Coggiola, Maurizio
Pira, Enrico
Scarmozzino, Antonio
La Valle, Giovanni
Cassoni, Paola
Cavallo, Rossana
author_facet Costa, Cristina
Migliore, Enrica
Galassi, Claudia
Scozzari, Gitana
Ciccone, Giovannino
Coggiola, Maurizio
Pira, Enrico
Scarmozzino, Antonio
La Valle, Giovanni
Cassoni, Paola
Cavallo, Rossana
author_sort Costa, Cristina
collection PubMed
description We aimed at evaluating quantitative IgG response to BNT162b2 COVID-19 vaccine among health care workers (HCW), and exploring the role of demographic, clinical, and occupational factors as predictors of IgG levels. On May 2021, among 6687 HCW at the largest tertiary care University-Hospital of Northwestern Italy, at a median of 15 weeks (Interquartile range-IQR 13.6–16.0) after second-dose, serological response was present in 99.8%. Seropositivity was >97% in all the subgroups, except those self-reporting immunodeficiency (94.9%). Overall, the median serological IgG value was 990 BAU/mL (IQR 551–1870), with most of subjects with previous SARS-CoV-2 infection or with shorter time lapse (2–8 weeks) between vaccination and serology with values in the highest quintile (>2080). At multivariable analysis, significant predictors of lower values were increasing age, male, current smoking, immunodeficiency, recent occupational contacts, and increasing time lapse from vaccination; conversely, previous infection and recent household contacts were significantly associated with higher IgG levels. Subjects with previous infection kept a very high level (around 2000 BAU/mL) up to 120 days. These results, besides supporting a high serological response up to 4–5 months, suggest predictive factors of faster decay of IgG levels that could be useful in tailoring vaccination strategies.
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spelling pubmed-89554192022-03-26 Factors Influencing Level and Persistence of Anti SARS-CoV-2 IgG after BNT162b2 Vaccine: Evidence from a Large Cohort of Healthcare Workers Costa, Cristina Migliore, Enrica Galassi, Claudia Scozzari, Gitana Ciccone, Giovannino Coggiola, Maurizio Pira, Enrico Scarmozzino, Antonio La Valle, Giovanni Cassoni, Paola Cavallo, Rossana Vaccines (Basel) Article We aimed at evaluating quantitative IgG response to BNT162b2 COVID-19 vaccine among health care workers (HCW), and exploring the role of demographic, clinical, and occupational factors as predictors of IgG levels. On May 2021, among 6687 HCW at the largest tertiary care University-Hospital of Northwestern Italy, at a median of 15 weeks (Interquartile range-IQR 13.6–16.0) after second-dose, serological response was present in 99.8%. Seropositivity was >97% in all the subgroups, except those self-reporting immunodeficiency (94.9%). Overall, the median serological IgG value was 990 BAU/mL (IQR 551–1870), with most of subjects with previous SARS-CoV-2 infection or with shorter time lapse (2–8 weeks) between vaccination and serology with values in the highest quintile (>2080). At multivariable analysis, significant predictors of lower values were increasing age, male, current smoking, immunodeficiency, recent occupational contacts, and increasing time lapse from vaccination; conversely, previous infection and recent household contacts were significantly associated with higher IgG levels. Subjects with previous infection kept a very high level (around 2000 BAU/mL) up to 120 days. These results, besides supporting a high serological response up to 4–5 months, suggest predictive factors of faster decay of IgG levels that could be useful in tailoring vaccination strategies. MDPI 2022-03-18 /pmc/articles/PMC8955419/ /pubmed/35335105 http://dx.doi.org/10.3390/vaccines10030474 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Costa, Cristina
Migliore, Enrica
Galassi, Claudia
Scozzari, Gitana
Ciccone, Giovannino
Coggiola, Maurizio
Pira, Enrico
Scarmozzino, Antonio
La Valle, Giovanni
Cassoni, Paola
Cavallo, Rossana
Factors Influencing Level and Persistence of Anti SARS-CoV-2 IgG after BNT162b2 Vaccine: Evidence from a Large Cohort of Healthcare Workers
title Factors Influencing Level and Persistence of Anti SARS-CoV-2 IgG after BNT162b2 Vaccine: Evidence from a Large Cohort of Healthcare Workers
title_full Factors Influencing Level and Persistence of Anti SARS-CoV-2 IgG after BNT162b2 Vaccine: Evidence from a Large Cohort of Healthcare Workers
title_fullStr Factors Influencing Level and Persistence of Anti SARS-CoV-2 IgG after BNT162b2 Vaccine: Evidence from a Large Cohort of Healthcare Workers
title_full_unstemmed Factors Influencing Level and Persistence of Anti SARS-CoV-2 IgG after BNT162b2 Vaccine: Evidence from a Large Cohort of Healthcare Workers
title_short Factors Influencing Level and Persistence of Anti SARS-CoV-2 IgG after BNT162b2 Vaccine: Evidence from a Large Cohort of Healthcare Workers
title_sort factors influencing level and persistence of anti sars-cov-2 igg after bnt162b2 vaccine: evidence from a large cohort of healthcare workers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955419/
https://www.ncbi.nlm.nih.gov/pubmed/35335105
http://dx.doi.org/10.3390/vaccines10030474
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