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Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up
Coronary artery disease (CAD) is a common chronic condition in the elderly. However, the earlier CAD begins, the stronger its impact on lifestyle and costs of health and social care. The present study analyzes clinical and angiographic features and the outcome of very young patients undergoing coron...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955526/ https://www.ncbi.nlm.nih.gov/pubmed/35323630 http://dx.doi.org/10.3390/jcdd9030082 |
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author | Juan-Salvadores, Pablo Jiménez Díaz, Víctor Alfonso Iglesia Carreño, Cristina Guitián González, Alba Veiga, Cesar Martínez Reglero, Cristina Baz Alonso, José Antonio Caamaño Isorna, Francisco Iñiguez Romo, Andrés |
author_facet | Juan-Salvadores, Pablo Jiménez Díaz, Víctor Alfonso Iglesia Carreño, Cristina Guitián González, Alba Veiga, Cesar Martínez Reglero, Cristina Baz Alonso, José Antonio Caamaño Isorna, Francisco Iñiguez Romo, Andrés |
author_sort | Juan-Salvadores, Pablo |
collection | PubMed |
description | Coronary artery disease (CAD) is a common chronic condition in the elderly. However, the earlier CAD begins, the stronger its impact on lifestyle and costs of health and social care. The present study analyzes clinical and angiographic features and the outcome of very young patients undergoing coronary angiography due to suspected CAD, including a nested case-control study of ≤40-year-old patients referred for coronary angiography. Patients were divided into two groups: cases with significant angiographic stenosis, and controls with non-significant stenosis. Of the 19,321 coronary angiographies performed in our center in a period of 10 years, 504 (2.6%) were in patients ≤40 years. The most common cardiovascular risk factors for significant CAD were smoking (OR 2.96; 95% CI 1.65–5.37), dyslipidemia (OR 2.18; 95% CI 1.27–3.82), and family history of CAD (OR 1.95; 95% CI 1.05–3.75). The incidence of major adverse cardiovascular events (MACE) at follow-up was significantly higher in the cases compared to controls (HR 2.71; 95% CI 1.44–5.11). Three conventional coronary risk factors were directly related to the early signs of CAD. MACE in the long-term follow-up is associated to dyslipidaemia and hypertriglyceridemia. Focusing efforts for the adequate control of CAD in young patients is a priority given the high socio-medical cost that this disease entails to society. |
format | Online Article Text |
id | pubmed-8955526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89555262022-03-26 Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up Juan-Salvadores, Pablo Jiménez Díaz, Víctor Alfonso Iglesia Carreño, Cristina Guitián González, Alba Veiga, Cesar Martínez Reglero, Cristina Baz Alonso, José Antonio Caamaño Isorna, Francisco Iñiguez Romo, Andrés J Cardiovasc Dev Dis Article Coronary artery disease (CAD) is a common chronic condition in the elderly. However, the earlier CAD begins, the stronger its impact on lifestyle and costs of health and social care. The present study analyzes clinical and angiographic features and the outcome of very young patients undergoing coronary angiography due to suspected CAD, including a nested case-control study of ≤40-year-old patients referred for coronary angiography. Patients were divided into two groups: cases with significant angiographic stenosis, and controls with non-significant stenosis. Of the 19,321 coronary angiographies performed in our center in a period of 10 years, 504 (2.6%) were in patients ≤40 years. The most common cardiovascular risk factors for significant CAD were smoking (OR 2.96; 95% CI 1.65–5.37), dyslipidemia (OR 2.18; 95% CI 1.27–3.82), and family history of CAD (OR 1.95; 95% CI 1.05–3.75). The incidence of major adverse cardiovascular events (MACE) at follow-up was significantly higher in the cases compared to controls (HR 2.71; 95% CI 1.44–5.11). Three conventional coronary risk factors were directly related to the early signs of CAD. MACE in the long-term follow-up is associated to dyslipidaemia and hypertriglyceridemia. Focusing efforts for the adequate control of CAD in young patients is a priority given the high socio-medical cost that this disease entails to society. MDPI 2022-03-11 /pmc/articles/PMC8955526/ /pubmed/35323630 http://dx.doi.org/10.3390/jcdd9030082 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Juan-Salvadores, Pablo Jiménez Díaz, Víctor Alfonso Iglesia Carreño, Cristina Guitián González, Alba Veiga, Cesar Martínez Reglero, Cristina Baz Alonso, José Antonio Caamaño Isorna, Francisco Iñiguez Romo, Andrés Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up |
title | Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up |
title_full | Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up |
title_fullStr | Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up |
title_full_unstemmed | Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up |
title_short | Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up |
title_sort | coronary artery disease in very young patients: analysis of risk factors and long-term follow-up |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955526/ https://www.ncbi.nlm.nih.gov/pubmed/35323630 http://dx.doi.org/10.3390/jcdd9030082 |
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