Cargando…

Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up

Coronary artery disease (CAD) is a common chronic condition in the elderly. However, the earlier CAD begins, the stronger its impact on lifestyle and costs of health and social care. The present study analyzes clinical and angiographic features and the outcome of very young patients undergoing coron...

Descripción completa

Detalles Bibliográficos
Autores principales: Juan-Salvadores, Pablo, Jiménez Díaz, Víctor Alfonso, Iglesia Carreño, Cristina, Guitián González, Alba, Veiga, Cesar, Martínez Reglero, Cristina, Baz Alonso, José Antonio, Caamaño Isorna, Francisco, Iñiguez Romo, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955526/
https://www.ncbi.nlm.nih.gov/pubmed/35323630
http://dx.doi.org/10.3390/jcdd9030082
_version_ 1784676357476712448
author Juan-Salvadores, Pablo
Jiménez Díaz, Víctor Alfonso
Iglesia Carreño, Cristina
Guitián González, Alba
Veiga, Cesar
Martínez Reglero, Cristina
Baz Alonso, José Antonio
Caamaño Isorna, Francisco
Iñiguez Romo, Andrés
author_facet Juan-Salvadores, Pablo
Jiménez Díaz, Víctor Alfonso
Iglesia Carreño, Cristina
Guitián González, Alba
Veiga, Cesar
Martínez Reglero, Cristina
Baz Alonso, José Antonio
Caamaño Isorna, Francisco
Iñiguez Romo, Andrés
author_sort Juan-Salvadores, Pablo
collection PubMed
description Coronary artery disease (CAD) is a common chronic condition in the elderly. However, the earlier CAD begins, the stronger its impact on lifestyle and costs of health and social care. The present study analyzes clinical and angiographic features and the outcome of very young patients undergoing coronary angiography due to suspected CAD, including a nested case-control study of ≤40-year-old patients referred for coronary angiography. Patients were divided into two groups: cases with significant angiographic stenosis, and controls with non-significant stenosis. Of the 19,321 coronary angiographies performed in our center in a period of 10 years, 504 (2.6%) were in patients ≤40 years. The most common cardiovascular risk factors for significant CAD were smoking (OR 2.96; 95% CI 1.65–5.37), dyslipidemia (OR 2.18; 95% CI 1.27–3.82), and family history of CAD (OR 1.95; 95% CI 1.05–3.75). The incidence of major adverse cardiovascular events (MACE) at follow-up was significantly higher in the cases compared to controls (HR 2.71; 95% CI 1.44–5.11). Three conventional coronary risk factors were directly related to the early signs of CAD. MACE in the long-term follow-up is associated to dyslipidaemia and hypertriglyceridemia. Focusing efforts for the adequate control of CAD in young patients is a priority given the high socio-medical cost that this disease entails to society.
format Online
Article
Text
id pubmed-8955526
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89555262022-03-26 Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up Juan-Salvadores, Pablo Jiménez Díaz, Víctor Alfonso Iglesia Carreño, Cristina Guitián González, Alba Veiga, Cesar Martínez Reglero, Cristina Baz Alonso, José Antonio Caamaño Isorna, Francisco Iñiguez Romo, Andrés J Cardiovasc Dev Dis Article Coronary artery disease (CAD) is a common chronic condition in the elderly. However, the earlier CAD begins, the stronger its impact on lifestyle and costs of health and social care. The present study analyzes clinical and angiographic features and the outcome of very young patients undergoing coronary angiography due to suspected CAD, including a nested case-control study of ≤40-year-old patients referred for coronary angiography. Patients were divided into two groups: cases with significant angiographic stenosis, and controls with non-significant stenosis. Of the 19,321 coronary angiographies performed in our center in a period of 10 years, 504 (2.6%) were in patients ≤40 years. The most common cardiovascular risk factors for significant CAD were smoking (OR 2.96; 95% CI 1.65–5.37), dyslipidemia (OR 2.18; 95% CI 1.27–3.82), and family history of CAD (OR 1.95; 95% CI 1.05–3.75). The incidence of major adverse cardiovascular events (MACE) at follow-up was significantly higher in the cases compared to controls (HR 2.71; 95% CI 1.44–5.11). Three conventional coronary risk factors were directly related to the early signs of CAD. MACE in the long-term follow-up is associated to dyslipidaemia and hypertriglyceridemia. Focusing efforts for the adequate control of CAD in young patients is a priority given the high socio-medical cost that this disease entails to society. MDPI 2022-03-11 /pmc/articles/PMC8955526/ /pubmed/35323630 http://dx.doi.org/10.3390/jcdd9030082 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Juan-Salvadores, Pablo
Jiménez Díaz, Víctor Alfonso
Iglesia Carreño, Cristina
Guitián González, Alba
Veiga, Cesar
Martínez Reglero, Cristina
Baz Alonso, José Antonio
Caamaño Isorna, Francisco
Iñiguez Romo, Andrés
Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up
title Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up
title_full Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up
title_fullStr Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up
title_full_unstemmed Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up
title_short Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up
title_sort coronary artery disease in very young patients: analysis of risk factors and long-term follow-up
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955526/
https://www.ncbi.nlm.nih.gov/pubmed/35323630
http://dx.doi.org/10.3390/jcdd9030082
work_keys_str_mv AT juansalvadorespablo coronaryarterydiseaseinveryyoungpatientsanalysisofriskfactorsandlongtermfollowup
AT jimenezdiazvictoralfonso coronaryarterydiseaseinveryyoungpatientsanalysisofriskfactorsandlongtermfollowup
AT iglesiacarrenocristina coronaryarterydiseaseinveryyoungpatientsanalysisofriskfactorsandlongtermfollowup
AT guitiangonzalezalba coronaryarterydiseaseinveryyoungpatientsanalysisofriskfactorsandlongtermfollowup
AT veigacesar coronaryarterydiseaseinveryyoungpatientsanalysisofriskfactorsandlongtermfollowup
AT martinezreglerocristina coronaryarterydiseaseinveryyoungpatientsanalysisofriskfactorsandlongtermfollowup
AT bazalonsojoseantonio coronaryarterydiseaseinveryyoungpatientsanalysisofriskfactorsandlongtermfollowup
AT caamanoisornafrancisco coronaryarterydiseaseinveryyoungpatientsanalysisofriskfactorsandlongtermfollowup
AT iniguezromoandres coronaryarterydiseaseinveryyoungpatientsanalysisofriskfactorsandlongtermfollowup