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Metabolomic Studies in Inner Ear Pathologies
Sensorineural hearing loss is the most common sensory deficit. The etiologies of sensorineural hearing loss have been described and can be congenital or acquired. For congenital non-syndromic hearing loss, mutations that are related to sites of cochlear damage have been discovered (e.g., connexin pr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955628/ https://www.ncbi.nlm.nih.gov/pubmed/35323657 http://dx.doi.org/10.3390/metabo12030214 |
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author | Boullaud, Luc Blasco, Hélène Trinh, Thuy-Trân Bakhos, David |
author_facet | Boullaud, Luc Blasco, Hélène Trinh, Thuy-Trân Bakhos, David |
author_sort | Boullaud, Luc |
collection | PubMed |
description | Sensorineural hearing loss is the most common sensory deficit. The etiologies of sensorineural hearing loss have been described and can be congenital or acquired. For congenital non-syndromic hearing loss, mutations that are related to sites of cochlear damage have been discovered (e.g., connexin proteins, mitochondrial genes, etc.). For cytomegalovirus infection or auditory neuropathies, mechanisms are also well known and well researched. Although the etiologies of sensorineural hearing loss may be evident for some patients, the damaged sites and pathological mechanisms remain unclear for patients with progressive post-lingual hearing loss. Metabolomics is an emerging technique in which all metabolites present in a sample at a given time are analyzed, reflecting a physiological state. The objective of this study was to review the literature on the use of metabolomics in hearing loss. The findings of this review suggest that metabolomic studies may help to develop objective tests for diagnosis and personalized treatment. |
format | Online Article Text |
id | pubmed-8955628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89556282022-03-26 Metabolomic Studies in Inner Ear Pathologies Boullaud, Luc Blasco, Hélène Trinh, Thuy-Trân Bakhos, David Metabolites Systematic Review Sensorineural hearing loss is the most common sensory deficit. The etiologies of sensorineural hearing loss have been described and can be congenital or acquired. For congenital non-syndromic hearing loss, mutations that are related to sites of cochlear damage have been discovered (e.g., connexin proteins, mitochondrial genes, etc.). For cytomegalovirus infection or auditory neuropathies, mechanisms are also well known and well researched. Although the etiologies of sensorineural hearing loss may be evident for some patients, the damaged sites and pathological mechanisms remain unclear for patients with progressive post-lingual hearing loss. Metabolomics is an emerging technique in which all metabolites present in a sample at a given time are analyzed, reflecting a physiological state. The objective of this study was to review the literature on the use of metabolomics in hearing loss. The findings of this review suggest that metabolomic studies may help to develop objective tests for diagnosis and personalized treatment. MDPI 2022-02-26 /pmc/articles/PMC8955628/ /pubmed/35323657 http://dx.doi.org/10.3390/metabo12030214 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Boullaud, Luc Blasco, Hélène Trinh, Thuy-Trân Bakhos, David Metabolomic Studies in Inner Ear Pathologies |
title | Metabolomic Studies in Inner Ear Pathologies |
title_full | Metabolomic Studies in Inner Ear Pathologies |
title_fullStr | Metabolomic Studies in Inner Ear Pathologies |
title_full_unstemmed | Metabolomic Studies in Inner Ear Pathologies |
title_short | Metabolomic Studies in Inner Ear Pathologies |
title_sort | metabolomic studies in inner ear pathologies |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955628/ https://www.ncbi.nlm.nih.gov/pubmed/35323657 http://dx.doi.org/10.3390/metabo12030214 |
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