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Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease
Aspirin-exacerbated respiratory disease (AERD) is characterized by overproduction of the pro-inflammatory eicosanoids. Although immunoglobulin E-mediated sensitization to aeroallergens is common among AERD patients, it does not belong to the defining disease characteristics. In this study of 133 AER...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955638/ https://www.ncbi.nlm.nih.gov/pubmed/35330446 http://dx.doi.org/10.3390/jpm12030447 |
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author | Potaczek, Daniel P. Trąd, Gabriela Sanak, Marek Garn, Holger Mastalerz, Lucyna |
author_facet | Potaczek, Daniel P. Trąd, Gabriela Sanak, Marek Garn, Holger Mastalerz, Lucyna |
author_sort | Potaczek, Daniel P. |
collection | PubMed |
description | Aspirin-exacerbated respiratory disease (AERD) is characterized by overproduction of the pro-inflammatory eicosanoids. Although immunoglobulin E-mediated sensitization to aeroallergens is common among AERD patients, it does not belong to the defining disease characteristics. In this study of 133 AERD patients, we sought to find a relationship between sensitization to aeroallergens and local (leukotriene E(4), prostaglandin E(2) and prostaglandin D(2)) and/or systemic (leukotriene E(4)) production of arachidonic acid metabolites. Interestingly, a negative association between pro-inflammatory eicosanoid levels in induced sputum supernatant or urine and sensitization to aeroallergens was observed. This inverse relationship might suggest the presence of a protective effect of atopic sensitization to aeroallergens against stronger local airway inflammation and higher systemic AERD-related inflammatory activity. |
format | Online Article Text |
id | pubmed-8955638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89556382022-03-26 Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease Potaczek, Daniel P. Trąd, Gabriela Sanak, Marek Garn, Holger Mastalerz, Lucyna J Pers Med Article Aspirin-exacerbated respiratory disease (AERD) is characterized by overproduction of the pro-inflammatory eicosanoids. Although immunoglobulin E-mediated sensitization to aeroallergens is common among AERD patients, it does not belong to the defining disease characteristics. In this study of 133 AERD patients, we sought to find a relationship between sensitization to aeroallergens and local (leukotriene E(4), prostaglandin E(2) and prostaglandin D(2)) and/or systemic (leukotriene E(4)) production of arachidonic acid metabolites. Interestingly, a negative association between pro-inflammatory eicosanoid levels in induced sputum supernatant or urine and sensitization to aeroallergens was observed. This inverse relationship might suggest the presence of a protective effect of atopic sensitization to aeroallergens against stronger local airway inflammation and higher systemic AERD-related inflammatory activity. MDPI 2022-03-11 /pmc/articles/PMC8955638/ /pubmed/35330446 http://dx.doi.org/10.3390/jpm12030447 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Potaczek, Daniel P. Trąd, Gabriela Sanak, Marek Garn, Holger Mastalerz, Lucyna Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease |
title | Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease |
title_full | Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease |
title_fullStr | Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease |
title_full_unstemmed | Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease |
title_short | Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease |
title_sort | local and systemic production of pro-inflammatory eicosanoids is inversely related to sensitization to aeroallergens in patients with aspirin-exacerbated respiratory disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955638/ https://www.ncbi.nlm.nih.gov/pubmed/35330446 http://dx.doi.org/10.3390/jpm12030447 |
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