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Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease

Aspirin-exacerbated respiratory disease (AERD) is characterized by overproduction of the pro-inflammatory eicosanoids. Although immunoglobulin E-mediated sensitization to aeroallergens is common among AERD patients, it does not belong to the defining disease characteristics. In this study of 133 AER...

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Autores principales: Potaczek, Daniel P., Trąd, Gabriela, Sanak, Marek, Garn, Holger, Mastalerz, Lucyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955638/
https://www.ncbi.nlm.nih.gov/pubmed/35330446
http://dx.doi.org/10.3390/jpm12030447
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author Potaczek, Daniel P.
Trąd, Gabriela
Sanak, Marek
Garn, Holger
Mastalerz, Lucyna
author_facet Potaczek, Daniel P.
Trąd, Gabriela
Sanak, Marek
Garn, Holger
Mastalerz, Lucyna
author_sort Potaczek, Daniel P.
collection PubMed
description Aspirin-exacerbated respiratory disease (AERD) is characterized by overproduction of the pro-inflammatory eicosanoids. Although immunoglobulin E-mediated sensitization to aeroallergens is common among AERD patients, it does not belong to the defining disease characteristics. In this study of 133 AERD patients, we sought to find a relationship between sensitization to aeroallergens and local (leukotriene E(4), prostaglandin E(2) and prostaglandin D(2)) and/or systemic (leukotriene E(4)) production of arachidonic acid metabolites. Interestingly, a negative association between pro-inflammatory eicosanoid levels in induced sputum supernatant or urine and sensitization to aeroallergens was observed. This inverse relationship might suggest the presence of a protective effect of atopic sensitization to aeroallergens against stronger local airway inflammation and higher systemic AERD-related inflammatory activity.
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spelling pubmed-89556382022-03-26 Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease Potaczek, Daniel P. Trąd, Gabriela Sanak, Marek Garn, Holger Mastalerz, Lucyna J Pers Med Article Aspirin-exacerbated respiratory disease (AERD) is characterized by overproduction of the pro-inflammatory eicosanoids. Although immunoglobulin E-mediated sensitization to aeroallergens is common among AERD patients, it does not belong to the defining disease characteristics. In this study of 133 AERD patients, we sought to find a relationship between sensitization to aeroallergens and local (leukotriene E(4), prostaglandin E(2) and prostaglandin D(2)) and/or systemic (leukotriene E(4)) production of arachidonic acid metabolites. Interestingly, a negative association between pro-inflammatory eicosanoid levels in induced sputum supernatant or urine and sensitization to aeroallergens was observed. This inverse relationship might suggest the presence of a protective effect of atopic sensitization to aeroallergens against stronger local airway inflammation and higher systemic AERD-related inflammatory activity. MDPI 2022-03-11 /pmc/articles/PMC8955638/ /pubmed/35330446 http://dx.doi.org/10.3390/jpm12030447 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Potaczek, Daniel P.
Trąd, Gabriela
Sanak, Marek
Garn, Holger
Mastalerz, Lucyna
Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease
title Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease
title_full Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease
title_fullStr Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease
title_full_unstemmed Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease
title_short Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease
title_sort local and systemic production of pro-inflammatory eicosanoids is inversely related to sensitization to aeroallergens in patients with aspirin-exacerbated respiratory disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955638/
https://www.ncbi.nlm.nih.gov/pubmed/35330446
http://dx.doi.org/10.3390/jpm12030447
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