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Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review
Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs and symptoms are nonspecific. Joint amyloid...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955677/ https://www.ncbi.nlm.nih.gov/pubmed/35323175 http://dx.doi.org/10.3390/hematolrep14010004 |
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author | Mazziotta, Francesco Buda, Gabriele Del Giudice, Maria Livia Orciuolo, Enrico Benedetti, Edoardo Masini, Matilde De Tata, Vincenzo Galimberti, Sara Petrini, Mario |
author_facet | Mazziotta, Francesco Buda, Gabriele Del Giudice, Maria Livia Orciuolo, Enrico Benedetti, Edoardo Masini, Matilde De Tata, Vincenzo Galimberti, Sara Petrini, Mario |
author_sort | Mazziotta, Francesco |
collection | PubMed |
description | Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs and symptoms are nonspecific. Joint amyloidosis, in particular, may be confused with degenerative or autoimmune diseases. When it is associated with MM, it can significantly precede the diagnosis of the latter. We describe a case report of a woman of Nigerian heritage diagnosed with MM with widespread joint manifestations compatible with a diagnosis of amyloidosis, which had preceded the diagnosis of MM and benefited from MM treatment. Faced with the suspicion of amyloidosis, if confirmed, this can be used to anticipate the diagnosis of MM, and at a more advanced stage, it can benefit from the treatment of the MM. |
format | Online Article Text |
id | pubmed-8955677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89556772022-03-26 Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review Mazziotta, Francesco Buda, Gabriele Del Giudice, Maria Livia Orciuolo, Enrico Benedetti, Edoardo Masini, Matilde De Tata, Vincenzo Galimberti, Sara Petrini, Mario Hematol Rep Case Report Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs and symptoms are nonspecific. Joint amyloidosis, in particular, may be confused with degenerative or autoimmune diseases. When it is associated with MM, it can significantly precede the diagnosis of the latter. We describe a case report of a woman of Nigerian heritage diagnosed with MM with widespread joint manifestations compatible with a diagnosis of amyloidosis, which had preceded the diagnosis of MM and benefited from MM treatment. Faced with the suspicion of amyloidosis, if confirmed, this can be used to anticipate the diagnosis of MM, and at a more advanced stage, it can benefit from the treatment of the MM. MDPI 2022-03-02 /pmc/articles/PMC8955677/ /pubmed/35323175 http://dx.doi.org/10.3390/hematolrep14010004 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Mazziotta, Francesco Buda, Gabriele Del Giudice, Maria Livia Orciuolo, Enrico Benedetti, Edoardo Masini, Matilde De Tata, Vincenzo Galimberti, Sara Petrini, Mario Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review |
title | Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review |
title_full | Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review |
title_fullStr | Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review |
title_full_unstemmed | Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review |
title_short | Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review |
title_sort | joint pain and arthritis as first clinical manifestation of systemic amyloidosis and multiple myeloma: case report and brief literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955677/ https://www.ncbi.nlm.nih.gov/pubmed/35323175 http://dx.doi.org/10.3390/hematolrep14010004 |
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