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Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review

Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs and symptoms are nonspecific. Joint amyloid...

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Autores principales: Mazziotta, Francesco, Buda, Gabriele, Del Giudice, Maria Livia, Orciuolo, Enrico, Benedetti, Edoardo, Masini, Matilde, De Tata, Vincenzo, Galimberti, Sara, Petrini, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955677/
https://www.ncbi.nlm.nih.gov/pubmed/35323175
http://dx.doi.org/10.3390/hematolrep14010004
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author Mazziotta, Francesco
Buda, Gabriele
Del Giudice, Maria Livia
Orciuolo, Enrico
Benedetti, Edoardo
Masini, Matilde
De Tata, Vincenzo
Galimberti, Sara
Petrini, Mario
author_facet Mazziotta, Francesco
Buda, Gabriele
Del Giudice, Maria Livia
Orciuolo, Enrico
Benedetti, Edoardo
Masini, Matilde
De Tata, Vincenzo
Galimberti, Sara
Petrini, Mario
author_sort Mazziotta, Francesco
collection PubMed
description Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs and symptoms are nonspecific. Joint amyloidosis, in particular, may be confused with degenerative or autoimmune diseases. When it is associated with MM, it can significantly precede the diagnosis of the latter. We describe a case report of a woman of Nigerian heritage diagnosed with MM with widespread joint manifestations compatible with a diagnosis of amyloidosis, which had preceded the diagnosis of MM and benefited from MM treatment. Faced with the suspicion of amyloidosis, if confirmed, this can be used to anticipate the diagnosis of MM, and at a more advanced stage, it can benefit from the treatment of the MM.
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spelling pubmed-89556772022-03-26 Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review Mazziotta, Francesco Buda, Gabriele Del Giudice, Maria Livia Orciuolo, Enrico Benedetti, Edoardo Masini, Matilde De Tata, Vincenzo Galimberti, Sara Petrini, Mario Hematol Rep Case Report Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs and symptoms are nonspecific. Joint amyloidosis, in particular, may be confused with degenerative or autoimmune diseases. When it is associated with MM, it can significantly precede the diagnosis of the latter. We describe a case report of a woman of Nigerian heritage diagnosed with MM with widespread joint manifestations compatible with a diagnosis of amyloidosis, which had preceded the diagnosis of MM and benefited from MM treatment. Faced with the suspicion of amyloidosis, if confirmed, this can be used to anticipate the diagnosis of MM, and at a more advanced stage, it can benefit from the treatment of the MM. MDPI 2022-03-02 /pmc/articles/PMC8955677/ /pubmed/35323175 http://dx.doi.org/10.3390/hematolrep14010004 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Mazziotta, Francesco
Buda, Gabriele
Del Giudice, Maria Livia
Orciuolo, Enrico
Benedetti, Edoardo
Masini, Matilde
De Tata, Vincenzo
Galimberti, Sara
Petrini, Mario
Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review
title Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review
title_full Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review
title_fullStr Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review
title_full_unstemmed Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review
title_short Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review
title_sort joint pain and arthritis as first clinical manifestation of systemic amyloidosis and multiple myeloma: case report and brief literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955677/
https://www.ncbi.nlm.nih.gov/pubmed/35323175
http://dx.doi.org/10.3390/hematolrep14010004
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