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Age, Sex, Body Mass Index, Diet and Menopause Related Metabolites in a Large Homogeneous Alpine Cohort
Metabolomics in human serum samples provide a snapshot of the current metabolic state of an individuum. Metabolite concentrations are influenced by both genetic and environmental factors. Concentrations of certain metabolites can further depend on age, sex, menopause, and diet of study participants....
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955763/ https://www.ncbi.nlm.nih.gov/pubmed/35323648 http://dx.doi.org/10.3390/metabo12030205 |
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author | Verri Hernandes, Vinicius Dordevic, Nikola Hantikainen, Essi Marjatta Sigurdsson, Baldur Bragi Smárason, Sigurður Vidir Garcia-Larsen, Vanessa Gögele, Martin Caprioli, Giulia Bozzolan, Ilaria Pramstaller, Peter P. Rainer, Johannes |
author_facet | Verri Hernandes, Vinicius Dordevic, Nikola Hantikainen, Essi Marjatta Sigurdsson, Baldur Bragi Smárason, Sigurður Vidir Garcia-Larsen, Vanessa Gögele, Martin Caprioli, Giulia Bozzolan, Ilaria Pramstaller, Peter P. Rainer, Johannes |
author_sort | Verri Hernandes, Vinicius |
collection | PubMed |
description | Metabolomics in human serum samples provide a snapshot of the current metabolic state of an individuum. Metabolite concentrations are influenced by both genetic and environmental factors. Concentrations of certain metabolites can further depend on age, sex, menopause, and diet of study participants. A better understanding of these relationships is pivotal for the planning of metabolomics studies involving human subjects and interpretation of their results. We generated one of the largest single-site targeted metabolomics data sets consisting of 175 quantified metabolites in 6872 study participants. We identified metabolites significantly associated with age, sex, body mass index, diet, and menopausal status. While most of our results agree with previous large-scale studies, we also found novel associations including serotonin as a sex and BMI-related metabolite and sarcosine and C2 carnitine showing significantly higher concentrations in post-menopausal women. Finally, we observed strong associations between higher consumption of food items and certain metabolites, mostly phosphatidylcholines and lysophosphatidylcholines. Most, and the strongest, relationships were found for habitual meat intake while no significant relationships were found for most fruits, vegetables, and grain products. Summarizing, our results reconfirm findings from previous population-based studies on an independent cohort. Together, these findings will ultimately enable the consolidation of sets of metabolites which are related to age, sex, BMI, and menopause as well as to participants’ diet. |
format | Online Article Text |
id | pubmed-8955763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89557632022-03-26 Age, Sex, Body Mass Index, Diet and Menopause Related Metabolites in a Large Homogeneous Alpine Cohort Verri Hernandes, Vinicius Dordevic, Nikola Hantikainen, Essi Marjatta Sigurdsson, Baldur Bragi Smárason, Sigurður Vidir Garcia-Larsen, Vanessa Gögele, Martin Caprioli, Giulia Bozzolan, Ilaria Pramstaller, Peter P. Rainer, Johannes Metabolites Article Metabolomics in human serum samples provide a snapshot of the current metabolic state of an individuum. Metabolite concentrations are influenced by both genetic and environmental factors. Concentrations of certain metabolites can further depend on age, sex, menopause, and diet of study participants. A better understanding of these relationships is pivotal for the planning of metabolomics studies involving human subjects and interpretation of their results. We generated one of the largest single-site targeted metabolomics data sets consisting of 175 quantified metabolites in 6872 study participants. We identified metabolites significantly associated with age, sex, body mass index, diet, and menopausal status. While most of our results agree with previous large-scale studies, we also found novel associations including serotonin as a sex and BMI-related metabolite and sarcosine and C2 carnitine showing significantly higher concentrations in post-menopausal women. Finally, we observed strong associations between higher consumption of food items and certain metabolites, mostly phosphatidylcholines and lysophosphatidylcholines. Most, and the strongest, relationships were found for habitual meat intake while no significant relationships were found for most fruits, vegetables, and grain products. Summarizing, our results reconfirm findings from previous population-based studies on an independent cohort. Together, these findings will ultimately enable the consolidation of sets of metabolites which are related to age, sex, BMI, and menopause as well as to participants’ diet. MDPI 2022-02-24 /pmc/articles/PMC8955763/ /pubmed/35323648 http://dx.doi.org/10.3390/metabo12030205 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Verri Hernandes, Vinicius Dordevic, Nikola Hantikainen, Essi Marjatta Sigurdsson, Baldur Bragi Smárason, Sigurður Vidir Garcia-Larsen, Vanessa Gögele, Martin Caprioli, Giulia Bozzolan, Ilaria Pramstaller, Peter P. Rainer, Johannes Age, Sex, Body Mass Index, Diet and Menopause Related Metabolites in a Large Homogeneous Alpine Cohort |
title | Age, Sex, Body Mass Index, Diet and Menopause Related Metabolites in a Large Homogeneous Alpine Cohort |
title_full | Age, Sex, Body Mass Index, Diet and Menopause Related Metabolites in a Large Homogeneous Alpine Cohort |
title_fullStr | Age, Sex, Body Mass Index, Diet and Menopause Related Metabolites in a Large Homogeneous Alpine Cohort |
title_full_unstemmed | Age, Sex, Body Mass Index, Diet and Menopause Related Metabolites in a Large Homogeneous Alpine Cohort |
title_short | Age, Sex, Body Mass Index, Diet and Menopause Related Metabolites in a Large Homogeneous Alpine Cohort |
title_sort | age, sex, body mass index, diet and menopause related metabolites in a large homogeneous alpine cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955763/ https://www.ncbi.nlm.nih.gov/pubmed/35323648 http://dx.doi.org/10.3390/metabo12030205 |
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