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The Serum Profile of Transferrin Isoforms in Pancreatitis

Total transferrin concentration changes in acute-phase reactions. Additionally, the alteration of transferrin glycosylation in inflammations can occur. The aim of this study is to evaluate the effect of pancreatitis on the serum profile of transferrin isoforms. The tested groups consisted of 84 pati...

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Autores principales: Mucha, Agnieszka, Zaczek, Malgorzata, Kralisz, Michal, Gruszewska, Ewa, Cylwik, Bogdan, Panasiuk, Anatol, Chrostek, Lech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955842/
https://www.ncbi.nlm.nih.gov/pubmed/35329964
http://dx.doi.org/10.3390/jcm11061638
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author Mucha, Agnieszka
Zaczek, Malgorzata
Kralisz, Michal
Gruszewska, Ewa
Cylwik, Bogdan
Panasiuk, Anatol
Chrostek, Lech
author_facet Mucha, Agnieszka
Zaczek, Malgorzata
Kralisz, Michal
Gruszewska, Ewa
Cylwik, Bogdan
Panasiuk, Anatol
Chrostek, Lech
author_sort Mucha, Agnieszka
collection PubMed
description Total transferrin concentration changes in acute-phase reactions. Additionally, the alteration of transferrin glycosylation in inflammations can occur. The aim of this study is to evaluate the effect of pancreatitis on the serum profile of transferrin isoforms. The tested groups consisted of 84 patients with acute pancreatitis and 42 patients with chronic hepatitis. Transferrin isoforms were analyzed by capillary electrophoresis on a MINICAP electrophoretic system (Sebia, France). There was a significant decrease in the concentration of pentasialotransferrin in both acute and chronic pancreatitis, and a significant increase in tetrasialotransferrin in the acute pancreatitis group when compared to the control group. There were no significant changes in transferrin isoforms between the acute and chronic pancreatitis groups, and between the edematous and necrotizing forms of the disease. Considering the etiology of acute pancreatitis, we noticed higher values of bile acids and γ-glutamyltransferase in acute pancreatitis of alcoholic etiology than that in pancreatitis of other etiologies. In conclusion, the alterations in transferrin isoform profile in acute and chronic pancreatitis are not organ specific. Because similar changes were observed in hepatitis, we can conclude that the serum profile of transferrin isoforms is involved in the pathogenesis of the disease.
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spelling pubmed-89558422022-03-26 The Serum Profile of Transferrin Isoforms in Pancreatitis Mucha, Agnieszka Zaczek, Malgorzata Kralisz, Michal Gruszewska, Ewa Cylwik, Bogdan Panasiuk, Anatol Chrostek, Lech J Clin Med Article Total transferrin concentration changes in acute-phase reactions. Additionally, the alteration of transferrin glycosylation in inflammations can occur. The aim of this study is to evaluate the effect of pancreatitis on the serum profile of transferrin isoforms. The tested groups consisted of 84 patients with acute pancreatitis and 42 patients with chronic hepatitis. Transferrin isoforms were analyzed by capillary electrophoresis on a MINICAP electrophoretic system (Sebia, France). There was a significant decrease in the concentration of pentasialotransferrin in both acute and chronic pancreatitis, and a significant increase in tetrasialotransferrin in the acute pancreatitis group when compared to the control group. There were no significant changes in transferrin isoforms between the acute and chronic pancreatitis groups, and between the edematous and necrotizing forms of the disease. Considering the etiology of acute pancreatitis, we noticed higher values of bile acids and γ-glutamyltransferase in acute pancreatitis of alcoholic etiology than that in pancreatitis of other etiologies. In conclusion, the alterations in transferrin isoform profile in acute and chronic pancreatitis are not organ specific. Because similar changes were observed in hepatitis, we can conclude that the serum profile of transferrin isoforms is involved in the pathogenesis of the disease. MDPI 2022-03-16 /pmc/articles/PMC8955842/ /pubmed/35329964 http://dx.doi.org/10.3390/jcm11061638 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mucha, Agnieszka
Zaczek, Malgorzata
Kralisz, Michal
Gruszewska, Ewa
Cylwik, Bogdan
Panasiuk, Anatol
Chrostek, Lech
The Serum Profile of Transferrin Isoforms in Pancreatitis
title The Serum Profile of Transferrin Isoforms in Pancreatitis
title_full The Serum Profile of Transferrin Isoforms in Pancreatitis
title_fullStr The Serum Profile of Transferrin Isoforms in Pancreatitis
title_full_unstemmed The Serum Profile of Transferrin Isoforms in Pancreatitis
title_short The Serum Profile of Transferrin Isoforms in Pancreatitis
title_sort serum profile of transferrin isoforms in pancreatitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955842/
https://www.ncbi.nlm.nih.gov/pubmed/35329964
http://dx.doi.org/10.3390/jcm11061638
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