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Association between Proton Pump Inhibitor Use and Parkinson’s Disease in a Korean Population

Few studies have shown an increased risk of Parkinson’s disease (PD) with the use of proton pump inhibitors (PPIs), and the pathophysiological mechanism for this association has not been unveiled. This study examined the relationship between PPI use and PD in a Korean population. We investigated 302...

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Autores principales: Kim, Ji-Hee, Oh, Jae-Keun, Kim, Yoo-Hwan, Kwon, Mi-Jung, Kim, Joo-Hee, Choi, Hyo-Geun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955848/
https://www.ncbi.nlm.nih.gov/pubmed/35337125
http://dx.doi.org/10.3390/ph15030327
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author Kim, Ji-Hee
Oh, Jae-Keun
Kim, Yoo-Hwan
Kwon, Mi-Jung
Kim, Joo-Hee
Choi, Hyo-Geun
author_facet Kim, Ji-Hee
Oh, Jae-Keun
Kim, Yoo-Hwan
Kwon, Mi-Jung
Kim, Joo-Hee
Choi, Hyo-Geun
author_sort Kim, Ji-Hee
collection PubMed
description Few studies have shown an increased risk of Parkinson’s disease (PD) with the use of proton pump inhibitors (PPIs), and the pathophysiological mechanism for this association has not been unveiled. This study examined the relationship between PPI use and PD in a Korean population. We investigated 3026 PD patients and 12,104 controls who were matched by age, sex, income, and region of residence at a ratio of 1:4 in the Korean National Health Insurance Service, National Sample Cohort between 2002 and 2015. We estimated the associations between current and past use of PPIs and PD using odds ratios (ORs) and 95% confidence intervals (CIs) in a conditional/unconditional logistic regression after adjusting for probable confounders. Compared with PPI nonusers, both current users and past users had significantly greater odds of having PD, with ORs of 1.63 (95% CI = 1.44–1.84) and 1.12 (95% CI = 1.01–1.25), respectively. A significant association with PD was observed in individuals who used PPIs for 30–90 days and ≥90 days (OR = 1.26 and 1.64, 95% CI = 1.12–1.43 and 1.43–1.89) but not among those who used PPIs for <30 days. Both current and past use of PPIs associated with a higher probability of PD in the Korean population. Our study provides evidence regarding the association between PPI exposure and PD, but further investigation and possible explanations are warranted.
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spelling pubmed-89558482022-03-26 Association between Proton Pump Inhibitor Use and Parkinson’s Disease in a Korean Population Kim, Ji-Hee Oh, Jae-Keun Kim, Yoo-Hwan Kwon, Mi-Jung Kim, Joo-Hee Choi, Hyo-Geun Pharmaceuticals (Basel) Article Few studies have shown an increased risk of Parkinson’s disease (PD) with the use of proton pump inhibitors (PPIs), and the pathophysiological mechanism for this association has not been unveiled. This study examined the relationship between PPI use and PD in a Korean population. We investigated 3026 PD patients and 12,104 controls who were matched by age, sex, income, and region of residence at a ratio of 1:4 in the Korean National Health Insurance Service, National Sample Cohort between 2002 and 2015. We estimated the associations between current and past use of PPIs and PD using odds ratios (ORs) and 95% confidence intervals (CIs) in a conditional/unconditional logistic regression after adjusting for probable confounders. Compared with PPI nonusers, both current users and past users had significantly greater odds of having PD, with ORs of 1.63 (95% CI = 1.44–1.84) and 1.12 (95% CI = 1.01–1.25), respectively. A significant association with PD was observed in individuals who used PPIs for 30–90 days and ≥90 days (OR = 1.26 and 1.64, 95% CI = 1.12–1.43 and 1.43–1.89) but not among those who used PPIs for <30 days. Both current and past use of PPIs associated with a higher probability of PD in the Korean population. Our study provides evidence regarding the association between PPI exposure and PD, but further investigation and possible explanations are warranted. MDPI 2022-03-09 /pmc/articles/PMC8955848/ /pubmed/35337125 http://dx.doi.org/10.3390/ph15030327 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Ji-Hee
Oh, Jae-Keun
Kim, Yoo-Hwan
Kwon, Mi-Jung
Kim, Joo-Hee
Choi, Hyo-Geun
Association between Proton Pump Inhibitor Use and Parkinson’s Disease in a Korean Population
title Association between Proton Pump Inhibitor Use and Parkinson’s Disease in a Korean Population
title_full Association between Proton Pump Inhibitor Use and Parkinson’s Disease in a Korean Population
title_fullStr Association between Proton Pump Inhibitor Use and Parkinson’s Disease in a Korean Population
title_full_unstemmed Association between Proton Pump Inhibitor Use and Parkinson’s Disease in a Korean Population
title_short Association between Proton Pump Inhibitor Use and Parkinson’s Disease in a Korean Population
title_sort association between proton pump inhibitor use and parkinson’s disease in a korean population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955848/
https://www.ncbi.nlm.nih.gov/pubmed/35337125
http://dx.doi.org/10.3390/ph15030327
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