The WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders

Recent reports indicate that the hypoxia-induced factor (HIF1α) and the Warburg effect play an initiating role in glucotoxicity, which underlies disorders in metabolic diseases. WWOX has been identified as a HIF1α regulator. WWOX downregulation leads to an increased expression of HIF1α target genes...

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Detalles Bibliográficos
Autores principales: Baryła, Izabela, Styczeń-Binkowska, Ewa, Płuciennik, Elżbieta, Kośla, Katarzyna, Bednarek, Andrzej K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955937/
https://www.ncbi.nlm.nih.gov/pubmed/35328751
http://dx.doi.org/10.3390/ijms23063326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955937/
https://www.ncbi.nlm.nih.gov/pubmed/35328751
http://dx.doi.org/10.3390/ijms23063326

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