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A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review
The pathophysiology of Takotsubo Syndrome (TTS) is not completely understood and the trigger of sudden cardiac death (SCD) in TTS is not clear either. We therefore sought to find an association between TTS and primary electrical diseases. A total of 148 TTS patients were analyzed between 2003 and 20...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955983/ https://www.ncbi.nlm.nih.gov/pubmed/35323627 http://dx.doi.org/10.3390/jcdd9030079 |
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author | El-Battrawy, Ibrahim Erath, Julia W. Vamos, Mate Aweimer, Assem Mügge, Andreas Lang, Siegfried Ansari, Uzair Gietzen, Thorsten Akin, Ibrahim |
author_facet | El-Battrawy, Ibrahim Erath, Julia W. Vamos, Mate Aweimer, Assem Mügge, Andreas Lang, Siegfried Ansari, Uzair Gietzen, Thorsten Akin, Ibrahim |
author_sort | El-Battrawy, Ibrahim |
collection | PubMed |
description | The pathophysiology of Takotsubo Syndrome (TTS) is not completely understood and the trigger of sudden cardiac death (SCD) in TTS is not clear either. We therefore sought to find an association between TTS and primary electrical diseases. A total of 148 TTS patients were analyzed between 2003 and 2017 in a bi-centric manner. Additionally, a literature review was performed. The patients were included in an ongoing retrospective cohort database. The coexistence of TTS and primary electrical diseases was confirmed in five cases as the following: catecholaminergic polymorphic ventricular tachycardia (CPVT, 18-year-old female) (n = 1), LQTS 1 (72-year-old female and 65-year-old female) (n = 2), LQTS 2 (17-year-old female) (n = 1), and LQTS in the absence of mutations (22-year-old female). Four patients suffered from malignant tachyarrhythmia and recurrent syncope after TTS. Except for the CPVT patient and one LQTS 1 patient, all other cases underwent subcutaneous ICD implantation. An event recorder of the CPVT patient after starting beta-blocker did not detect arrhythmias. The diagnosis of primary electrical disease was in 80% of cases unmasked on a TTS event. This diagnosis triggered a family clinical and genetic screening confirming the diagnosis of primary electrical disease. A subsequent literature review identified five cases as the following: a congenital atrioventricular block (n = 1), a Jervell and Lange-Nielsen Syndrome (n = 1), and a family LQTS in the absence of a mutation (n = 2), LQTS 2 (n = 1). A primary electrical disease should be suspected in young and old TTS patients with a family history of sudden cardiac death. In suspected cases, e.g., ongoing QT interval prolongation, despite recovery of left ventricular ejection fraction a family screening is recommended. |
format | Online Article Text |
id | pubmed-8955983 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89559832022-03-26 A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review El-Battrawy, Ibrahim Erath, Julia W. Vamos, Mate Aweimer, Assem Mügge, Andreas Lang, Siegfried Ansari, Uzair Gietzen, Thorsten Akin, Ibrahim J Cardiovasc Dev Dis Article The pathophysiology of Takotsubo Syndrome (TTS) is not completely understood and the trigger of sudden cardiac death (SCD) in TTS is not clear either. We therefore sought to find an association between TTS and primary electrical diseases. A total of 148 TTS patients were analyzed between 2003 and 2017 in a bi-centric manner. Additionally, a literature review was performed. The patients were included in an ongoing retrospective cohort database. The coexistence of TTS and primary electrical diseases was confirmed in five cases as the following: catecholaminergic polymorphic ventricular tachycardia (CPVT, 18-year-old female) (n = 1), LQTS 1 (72-year-old female and 65-year-old female) (n = 2), LQTS 2 (17-year-old female) (n = 1), and LQTS in the absence of mutations (22-year-old female). Four patients suffered from malignant tachyarrhythmia and recurrent syncope after TTS. Except for the CPVT patient and one LQTS 1 patient, all other cases underwent subcutaneous ICD implantation. An event recorder of the CPVT patient after starting beta-blocker did not detect arrhythmias. The diagnosis of primary electrical disease was in 80% of cases unmasked on a TTS event. This diagnosis triggered a family clinical and genetic screening confirming the diagnosis of primary electrical disease. A subsequent literature review identified five cases as the following: a congenital atrioventricular block (n = 1), a Jervell and Lange-Nielsen Syndrome (n = 1), and a family LQTS in the absence of a mutation (n = 2), LQTS 2 (n = 1). A primary electrical disease should be suspected in young and old TTS patients with a family history of sudden cardiac death. In suspected cases, e.g., ongoing QT interval prolongation, despite recovery of left ventricular ejection fraction a family screening is recommended. MDPI 2022-03-09 /pmc/articles/PMC8955983/ /pubmed/35323627 http://dx.doi.org/10.3390/jcdd9030079 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article El-Battrawy, Ibrahim Erath, Julia W. Vamos, Mate Aweimer, Assem Mügge, Andreas Lang, Siegfried Ansari, Uzair Gietzen, Thorsten Akin, Ibrahim A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review |
title | A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review |
title_full | A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review |
title_fullStr | A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review |
title_full_unstemmed | A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review |
title_short | A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review |
title_sort | case series of concomitant cardiac electrical disease among takotsubo syndrome patients and literature review |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955983/ https://www.ncbi.nlm.nih.gov/pubmed/35323627 http://dx.doi.org/10.3390/jcdd9030079 |
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