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A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review

The pathophysiology of Takotsubo Syndrome (TTS) is not completely understood and the trigger of sudden cardiac death (SCD) in TTS is not clear either. We therefore sought to find an association between TTS and primary electrical diseases. A total of 148 TTS patients were analyzed between 2003 and 20...

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Autores principales: El-Battrawy, Ibrahim, Erath, Julia W., Vamos, Mate, Aweimer, Assem, Mügge, Andreas, Lang, Siegfried, Ansari, Uzair, Gietzen, Thorsten, Akin, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955983/
https://www.ncbi.nlm.nih.gov/pubmed/35323627
http://dx.doi.org/10.3390/jcdd9030079
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author El-Battrawy, Ibrahim
Erath, Julia W.
Vamos, Mate
Aweimer, Assem
Mügge, Andreas
Lang, Siegfried
Ansari, Uzair
Gietzen, Thorsten
Akin, Ibrahim
author_facet El-Battrawy, Ibrahim
Erath, Julia W.
Vamos, Mate
Aweimer, Assem
Mügge, Andreas
Lang, Siegfried
Ansari, Uzair
Gietzen, Thorsten
Akin, Ibrahim
author_sort El-Battrawy, Ibrahim
collection PubMed
description The pathophysiology of Takotsubo Syndrome (TTS) is not completely understood and the trigger of sudden cardiac death (SCD) in TTS is not clear either. We therefore sought to find an association between TTS and primary electrical diseases. A total of 148 TTS patients were analyzed between 2003 and 2017 in a bi-centric manner. Additionally, a literature review was performed. The patients were included in an ongoing retrospective cohort database. The coexistence of TTS and primary electrical diseases was confirmed in five cases as the following: catecholaminergic polymorphic ventricular tachycardia (CPVT, 18-year-old female) (n = 1), LQTS 1 (72-year-old female and 65-year-old female) (n = 2), LQTS 2 (17-year-old female) (n = 1), and LQTS in the absence of mutations (22-year-old female). Four patients suffered from malignant tachyarrhythmia and recurrent syncope after TTS. Except for the CPVT patient and one LQTS 1 patient, all other cases underwent subcutaneous ICD implantation. An event recorder of the CPVT patient after starting beta-blocker did not detect arrhythmias. The diagnosis of primary electrical disease was in 80% of cases unmasked on a TTS event. This diagnosis triggered a family clinical and genetic screening confirming the diagnosis of primary electrical disease. A subsequent literature review identified five cases as the following: a congenital atrioventricular block (n = 1), a Jervell and Lange-Nielsen Syndrome (n = 1), and a family LQTS in the absence of a mutation (n = 2), LQTS 2 (n = 1). A primary electrical disease should be suspected in young and old TTS patients with a family history of sudden cardiac death. In suspected cases, e.g., ongoing QT interval prolongation, despite recovery of left ventricular ejection fraction a family screening is recommended.
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spelling pubmed-89559832022-03-26 A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review El-Battrawy, Ibrahim Erath, Julia W. Vamos, Mate Aweimer, Assem Mügge, Andreas Lang, Siegfried Ansari, Uzair Gietzen, Thorsten Akin, Ibrahim J Cardiovasc Dev Dis Article The pathophysiology of Takotsubo Syndrome (TTS) is not completely understood and the trigger of sudden cardiac death (SCD) in TTS is not clear either. We therefore sought to find an association between TTS and primary electrical diseases. A total of 148 TTS patients were analyzed between 2003 and 2017 in a bi-centric manner. Additionally, a literature review was performed. The patients were included in an ongoing retrospective cohort database. The coexistence of TTS and primary electrical diseases was confirmed in five cases as the following: catecholaminergic polymorphic ventricular tachycardia (CPVT, 18-year-old female) (n = 1), LQTS 1 (72-year-old female and 65-year-old female) (n = 2), LQTS 2 (17-year-old female) (n = 1), and LQTS in the absence of mutations (22-year-old female). Four patients suffered from malignant tachyarrhythmia and recurrent syncope after TTS. Except for the CPVT patient and one LQTS 1 patient, all other cases underwent subcutaneous ICD implantation. An event recorder of the CPVT patient after starting beta-blocker did not detect arrhythmias. The diagnosis of primary electrical disease was in 80% of cases unmasked on a TTS event. This diagnosis triggered a family clinical and genetic screening confirming the diagnosis of primary electrical disease. A subsequent literature review identified five cases as the following: a congenital atrioventricular block (n = 1), a Jervell and Lange-Nielsen Syndrome (n = 1), and a family LQTS in the absence of a mutation (n = 2), LQTS 2 (n = 1). A primary electrical disease should be suspected in young and old TTS patients with a family history of sudden cardiac death. In suspected cases, e.g., ongoing QT interval prolongation, despite recovery of left ventricular ejection fraction a family screening is recommended. MDPI 2022-03-09 /pmc/articles/PMC8955983/ /pubmed/35323627 http://dx.doi.org/10.3390/jcdd9030079 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
El-Battrawy, Ibrahim
Erath, Julia W.
Vamos, Mate
Aweimer, Assem
Mügge, Andreas
Lang, Siegfried
Ansari, Uzair
Gietzen, Thorsten
Akin, Ibrahim
A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review
title A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review
title_full A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review
title_fullStr A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review
title_full_unstemmed A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review
title_short A Case Series of Concomitant Cardiac Electrical Disease among Takotsubo Syndrome Patients and Literature Review
title_sort case series of concomitant cardiac electrical disease among takotsubo syndrome patients and literature review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955983/
https://www.ncbi.nlm.nih.gov/pubmed/35323627
http://dx.doi.org/10.3390/jcdd9030079
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