Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery

Extracellular vesicles (EVs) have been exploited as bio-inspired drug delivery systems (DDS) in the biomedical field. EVs have more advantages than synthetic nanoparticles: they are naturally equipped to cross extra- and intra-cellular barriers. Furthermore, they can deliver functional biomolecules...

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Detalles Bibliográficos
Autores principales: N’Diaye, Elisa-Racky, Orefice, Nicola Salvatore, Ghezzi, Catherine, Boumendjel, Ahcène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955996/
https://www.ncbi.nlm.nih.gov/pubmed/35336027
http://dx.doi.org/10.3390/pharmaceutics14030653
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author N’Diaye, Elisa-Racky
Orefice, Nicola Salvatore
Ghezzi, Catherine
Boumendjel, Ahcène
author_facet N’Diaye, Elisa-Racky
Orefice, Nicola Salvatore
Ghezzi, Catherine
Boumendjel, Ahcène
author_sort N’Diaye, Elisa-Racky
collection PubMed
description Extracellular vesicles (EVs) have been exploited as bio-inspired drug delivery systems (DDS) in the biomedical field. EVs have more advantages than synthetic nanoparticles: they are naturally equipped to cross extra- and intra-cellular barriers. Furthermore, they can deliver functional biomolecules from one cell to another even far away in the body. These advantages, along with obtained promising in vivo results, clearly evidenced the potential of EVs in drug delivery. Nevertheless, due to the difficulties of finding a chemical approach that is coherent with EVs’ rational clinical therapeutic use, those in the drug delivery community are expecting more from EVs’ use. Therefore, this review gathered knowledge of the current chemical approaches dealing with the conjugation of EVs for drugs and radiotracers.
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spelling pubmed-89559962022-03-26 Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery N’Diaye, Elisa-Racky Orefice, Nicola Salvatore Ghezzi, Catherine Boumendjel, Ahcène Pharmaceutics Review Extracellular vesicles (EVs) have been exploited as bio-inspired drug delivery systems (DDS) in the biomedical field. EVs have more advantages than synthetic nanoparticles: they are naturally equipped to cross extra- and intra-cellular barriers. Furthermore, they can deliver functional biomolecules from one cell to another even far away in the body. These advantages, along with obtained promising in vivo results, clearly evidenced the potential of EVs in drug delivery. Nevertheless, due to the difficulties of finding a chemical approach that is coherent with EVs’ rational clinical therapeutic use, those in the drug delivery community are expecting more from EVs’ use. Therefore, this review gathered knowledge of the current chemical approaches dealing with the conjugation of EVs for drugs and radiotracers. MDPI 2022-03-16 /pmc/articles/PMC8955996/ /pubmed/35336027 http://dx.doi.org/10.3390/pharmaceutics14030653 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
N’Diaye, Elisa-Racky
Orefice, Nicola Salvatore
Ghezzi, Catherine
Boumendjel, Ahcène
Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery
title Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery
title_full Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery
title_fullStr Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery
title_full_unstemmed Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery
title_short Chemically Modified Extracellular Vesicles and Applications in Radiolabeling and Drug Delivery
title_sort chemically modified extracellular vesicles and applications in radiolabeling and drug delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955996/
https://www.ncbi.nlm.nih.gov/pubmed/35336027
http://dx.doi.org/10.3390/pharmaceutics14030653
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