Cargando…

Pre-Clinical Tools for Predicting Drug Efficacy in Treatment of Tuberculosis

Combination therapy has, to some extent, been successful in limiting the emergence of drug-resistant tuberculosis. Drug combinations achieve this advantage by simultaneously acting on different targets and metabolic pathways. Additionally, drug combination therapies are shown to shorten the duration...

Descripción completa

Detalles Bibliográficos
Autores principales:	Margaryan, Hasmik, Evangelopoulos, Dimitrios D., Muraro Wildner, Leticia, McHugh, Timothy D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956012/ https://www.ncbi.nlm.nih.gov/pubmed/35336089 http://dx.doi.org/10.3390/microorganisms10030514

Ejemplares similares

Pediatric tuberculosis-human immunodeficiency virus co-infection in the United Kingdom highlights the need for better therapy monitoring tools: a case report
por: Evangelopoulos, Dimitrios, et al.
Publicado: (2017)

Culture-Free Enumeration of Mycobacterium tuberculosis in Mouse Tissues Using the Molecular Bacterial Load Assay for Preclinical Drug Development
por: Evangelopoulos, Dimitrios, et al.
Publicado: (2022)

An antibacterial from Hypericum acmosepalum inhibits ATP-dependent MurE ligase from Mycobacterium tuberculosis
por: Osman, Khadijo, et al.
Publicado: (2012)

Carprofen elicits pleiotropic mechanisms of bactericidal action with the potential to reverse antimicrobial drug resistance in tuberculosis
por: Maitra, Arundhati, et al.
Publicado: (2020)

Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy
por: Honeyborne, Isobella, et al.
Publicado: (2016)

2447. Ertapenem and Faropenem for the Treatment of Drug-Resistant Tuberculosis
por: Satta, Giovanni, et al.
Publicado: (2018)

Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition
por: Danquah, Cynthia A., et al.
Publicado: (2018)

Whole genome sequencing of drug resistant Mycobacterium tuberculosis isolates from a high burden tuberculosis region of North West Pakistan
por: Jabbar, Abdul, et al.
Publicado: (2019)

Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay
por: Guzman, Juan D, et al.
Publicado: (2013)

Performance of centralized versus decentralized tuberculosis treatment services in Southern Brazil, 2006–2015
por: Scheffer, Mara Cristina, et al.
Publicado: (2018)

Target antigens for Hs-14 monoclonal antibody and their various expression in normozoospermic and asthenozoospermic men
por: Capkova, Jana, et al.
Publicado: (2015)

A comparison of phenotypic and WGS drug susceptibility testing in Mycobacterium tuberculosis isolates from the Republic of Korea
por: Lee, Seung Heon, et al.
Publicado: (2023)

Reducing the risk of tuberculosis transmission for HCWs in high incidence settings
por: Paleckyte, Ana, et al.
Publicado: (2021)

Rifampicin Resistance in Tuberculosis Outbreak, London, England
por: Jenkins, Claire, et al.
Publicado: (2005)

Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics
por: Guzman, Juan David, et al.
Publicado: (2011)

Ertapenem and Faropenem against Mycobacterium tuberculosis: in vitro testing and comparison by macro and microdilution
por: Gonzalo, Ximena, et al.
Publicado: (2020)

Cell-wall synthesis and ribosome maturation are co-regulated by an RNA switch in Mycobacterium tuberculosis
por: Schwenk, Stefan, et al.
Publicado: (2018)

Safety and efficacy of low dose naltrexone in a long covid cohort; an interventional pre-post study
por: O'Kelly, Brendan, et al.
Publicado: (2022)

Whole genome sequencing and prediction of antimicrobial susceptibilities in non-tuberculous mycobacteria
por: Solanki, Priya, et al.
Publicado: (2022)

World TB Day 2016: an interview with leading experts in tuberculosis research
por: Phillips, Patrick P. J., et al.
Publicado: (2016)

Effect of study design and setting on tuberculosis clustering estimates using Mycobacterial Interspersed Repetitive Units-Variable Number Tandem Repeats (MIRU-VNTR): a systematic review
por: Mears, Jessica, et al.
Publicado: (2015)

Genetic variation in Mycobacterium tuberculosis isolates from a London outbreak associated with isoniazid resistance
por: Satta, Giovanni, et al.
Publicado: (2016)

Emergence of phenotypic and genotypic antimicrobial resistance in Mycobacterium tuberculosis
por: Kloprogge, Frank, et al.
Publicado: (2022)

Search for Antimicrobial Activity Among Fifty-Two Natural and Synthetic Compounds Identifies Anthraquinone and Polyacetylene Classes That Inhibit Mycobacterium tuberculosis
por: Pollo, Luiz A. E., et al.
Publicado: (2021)

The impact of COVID-19 on global tuberculosis control
por: Lipman, Marc, et al.
Publicado: (2021)

Improving the Drug Development Pipeline for Mycobacteria: Modelling Antibiotic Exposure in the Hollow Fibre Infection Model
por: Maitra, Arundhati, et al.
Publicado: (2021)

Characterization and possible function of glyceraldehyde-3-phosphate dehydrogenase-spermatogenic protein GAPDHS in mammalian sperm
por: Margaryan, Hasmik, et al.
Publicado: (2015)

Novel Vaccine Adjuvants as Key Tools for Improving Pandemic Preparedness
por: Pogostin, Brett H., et al.
Publicado: (2021)

Tuberculosis bacillary load, an early marker of disease severity: the utility of tuberculosis Molecular Bacterial Load Assay
por: Sabiiti, Wilber, et al.
Publicado: (2020)

Sequence analysis of the rifampicin resistance determining region (RRDR) of rpoB gene in multidrug resistance confirmed and newly diagnosed tuberculosis patients of Punjab, Pakistan
por: Hameed, Salma, et al.
Publicado: (2017)

Use of whole-genome sequencing to distinguish relapse from reinfection in a completed tuberculosis clinical trial
por: Witney, Adam A., et al.
Publicado: (2017)

Employing drug delivery strategies to create safe and effective pharmaceuticals for COVID‐19
por: McHugh, Kevin J.
Publicado: (2020)

Transgenerational inheritance of susceptibility to diabetes-induced male subfertility
por: Pavlinkova, Gabriela, et al.
Publicado: (2017)

Impact of birth and rearing type, as well as inaccuracy of recording, on pre-weaning lamb phenotypic and genetic merit for live weight
por: McHugh, N., et al.
Publicado: (2017)

Transcriptomic Signatures Predict Regulators of Drug Synergy and Clinical Regimen Efficacy against Tuberculosis
por: Ma, Shuyi, et al.
Publicado: (2019)

Harvest: an open-source tool for the validation and improvement of peptide identification metrics and fragmentation exploration
por: McHugh, Leo C, et al.
Publicado: (2010)

Baseline and acquired resistance to bedaquiline, linezolid and pretomanid, and impact on treatment outcomes in four tuberculosis clinical trials containing pretomanid
por: Timm, Juliano, et al.
Publicado: (2023)

Prevalence and correlates of the misuse of z-drugs and benzodiazepines in the National Survey on Drug Use and Health
por: McHugh, R. Kathryn, et al.
Publicado: (2023)

A Rapid and Sensitive Diagnostic Screening Assay for Detection of Mycobacteria Including Mycobacterium tuberculosis Directly from Sputum without Extraction
por: Cross, Lisa Jane, et al.
Publicado: (2015)

Tools to Alleviate the Drug Resistance in Mycobacterium tuberculosis
por: Rabaan, Ali A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7ce34u2stss0hq4r3hd4l897hl