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Optical Properties of Mn-Doped CuGa(In)S-ZnS Nanocrystals (NCs): Effects of Host NC and Mn Concentration

Time-gated fluorescence measurement (TGFM) using long-life fluorescence probes is a highly sensitive fluorescence-measurement technology due to the inherently high signal-to-background ratio. Although many probes for TGFM such as luminescent-metal-complex probes and lanthanide-doped nanoparticles ar...

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Autores principales: Lee, Bryan, Hegseth, Tristan, Zhu, Xiaoshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956066/
https://www.ncbi.nlm.nih.gov/pubmed/35335807
http://dx.doi.org/10.3390/nano12060994
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author Lee, Bryan
Hegseth, Tristan
Zhu, Xiaoshan
author_facet Lee, Bryan
Hegseth, Tristan
Zhu, Xiaoshan
author_sort Lee, Bryan
collection PubMed
description Time-gated fluorescence measurement (TGFM) using long-life fluorescence probes is a highly sensitive fluorescence-measurement technology due to the inherently high signal-to-background ratio. Although many probes for TGFM such as luminescent-metal-complex probes and lanthanide-doped nanoparticles are in development, they generally need sophisticated/expensive instruments for biosensing/imaging applications. Probes possessing high brightness, low-energy (visible light) excitation, and long lifetimes up to milliseconds of luminescence, are highly desired in order to simplify the optical and electronic design of time-gated instruments (e.g., adopting non-UV-grade optics or low-speed electronics), lower the instrument complexity and cost, and facilitate broader applications of TGFM. In this work, we developed Mn-doped CuGa(In)S-ZnS nanocrystals (NCs) using simple and standard synthetic steps to achieve all the desired optical features in order to investigate how the optical properties (fluorescence/absorption spectra, brightness, and lifetimes) of the Mn-doped NCs are affected by different host NCs and Mn concentrations in host NCs. With optimal synthetic conditions, a library of Mn-doped NCs was achieved that possessed high brightness (up to 47% quantum yield), low-energy excitation (by 405 nm visible light), and long lifetimes (up to 3.67 ms). Additionally, the time-domain fluorescence characteristics of optimal Mn-doped NCs were measured under pulsed 405 nm laser excitation and bandpass-filter-based emission collection. The measurement results indicate the feasibility of these optimal Mn-doped NCs in TGFM-based biosensing/imaging.
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spelling pubmed-89560662022-03-26 Optical Properties of Mn-Doped CuGa(In)S-ZnS Nanocrystals (NCs): Effects of Host NC and Mn Concentration Lee, Bryan Hegseth, Tristan Zhu, Xiaoshan Nanomaterials (Basel) Article Time-gated fluorescence measurement (TGFM) using long-life fluorescence probes is a highly sensitive fluorescence-measurement technology due to the inherently high signal-to-background ratio. Although many probes for TGFM such as luminescent-metal-complex probes and lanthanide-doped nanoparticles are in development, they generally need sophisticated/expensive instruments for biosensing/imaging applications. Probes possessing high brightness, low-energy (visible light) excitation, and long lifetimes up to milliseconds of luminescence, are highly desired in order to simplify the optical and electronic design of time-gated instruments (e.g., adopting non-UV-grade optics or low-speed electronics), lower the instrument complexity and cost, and facilitate broader applications of TGFM. In this work, we developed Mn-doped CuGa(In)S-ZnS nanocrystals (NCs) using simple and standard synthetic steps to achieve all the desired optical features in order to investigate how the optical properties (fluorescence/absorption spectra, brightness, and lifetimes) of the Mn-doped NCs are affected by different host NCs and Mn concentrations in host NCs. With optimal synthetic conditions, a library of Mn-doped NCs was achieved that possessed high brightness (up to 47% quantum yield), low-energy excitation (by 405 nm visible light), and long lifetimes (up to 3.67 ms). Additionally, the time-domain fluorescence characteristics of optimal Mn-doped NCs were measured under pulsed 405 nm laser excitation and bandpass-filter-based emission collection. The measurement results indicate the feasibility of these optimal Mn-doped NCs in TGFM-based biosensing/imaging. MDPI 2022-03-17 /pmc/articles/PMC8956066/ /pubmed/35335807 http://dx.doi.org/10.3390/nano12060994 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Bryan
Hegseth, Tristan
Zhu, Xiaoshan
Optical Properties of Mn-Doped CuGa(In)S-ZnS Nanocrystals (NCs): Effects of Host NC and Mn Concentration
title Optical Properties of Mn-Doped CuGa(In)S-ZnS Nanocrystals (NCs): Effects of Host NC and Mn Concentration
title_full Optical Properties of Mn-Doped CuGa(In)S-ZnS Nanocrystals (NCs): Effects of Host NC and Mn Concentration
title_fullStr Optical Properties of Mn-Doped CuGa(In)S-ZnS Nanocrystals (NCs): Effects of Host NC and Mn Concentration
title_full_unstemmed Optical Properties of Mn-Doped CuGa(In)S-ZnS Nanocrystals (NCs): Effects of Host NC and Mn Concentration
title_short Optical Properties of Mn-Doped CuGa(In)S-ZnS Nanocrystals (NCs): Effects of Host NC and Mn Concentration
title_sort optical properties of mn-doped cuga(in)s-zns nanocrystals (ncs): effects of host nc and mn concentration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956066/
https://www.ncbi.nlm.nih.gov/pubmed/35335807
http://dx.doi.org/10.3390/nano12060994
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