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Adaptation in cone photoreceptors contributes to an unexpected insensitivity of primate On parasol retinal ganglion cells to spatial structure in natural images

Neural circuits are constructed from nonlinear building blocks, and not surprisingly overall circuit behavior is often strongly nonlinear. But neural circuits can also behave near linearly, and some circuits shift from linear to nonlinear behavior depending on stimulus conditions. Such control of no...

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Detalles Bibliográficos
Autores principales: Yu, Zhou, Turner, Maxwell H, Baudin, Jacob, Rieke, Fred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956286/
https://www.ncbi.nlm.nih.gov/pubmed/35285798
http://dx.doi.org/10.7554/eLife.70611
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author Yu, Zhou
Turner, Maxwell H
Baudin, Jacob
Rieke, Fred
author_facet Yu, Zhou
Turner, Maxwell H
Baudin, Jacob
Rieke, Fred
author_sort Yu, Zhou
collection PubMed
description Neural circuits are constructed from nonlinear building blocks, and not surprisingly overall circuit behavior is often strongly nonlinear. But neural circuits can also behave near linearly, and some circuits shift from linear to nonlinear behavior depending on stimulus conditions. Such control of nonlinear circuit behavior is fundamental to neural computation. Here, we study a surprising stimulus dependence of the responses of macaque On (but not Off) parasol retinal ganglion cells: these cells respond nonlinearly to spatial structure in some stimuli but near linearly to spatial structure in others, including natural inputs. We show that these differences in the linearity of the integration of spatial inputs can be explained by a shift in the balance of excitatory and inhibitory synaptic inputs that originates at least partially from adaptation in the cone photoreceptors. More generally, this highlights how subtle asymmetries in signaling – here in the cone signals – can qualitatively alter circuit computation.
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spelling pubmed-89562862022-03-26 Adaptation in cone photoreceptors contributes to an unexpected insensitivity of primate On parasol retinal ganglion cells to spatial structure in natural images Yu, Zhou Turner, Maxwell H Baudin, Jacob Rieke, Fred eLife Neuroscience Neural circuits are constructed from nonlinear building blocks, and not surprisingly overall circuit behavior is often strongly nonlinear. But neural circuits can also behave near linearly, and some circuits shift from linear to nonlinear behavior depending on stimulus conditions. Such control of nonlinear circuit behavior is fundamental to neural computation. Here, we study a surprising stimulus dependence of the responses of macaque On (but not Off) parasol retinal ganglion cells: these cells respond nonlinearly to spatial structure in some stimuli but near linearly to spatial structure in others, including natural inputs. We show that these differences in the linearity of the integration of spatial inputs can be explained by a shift in the balance of excitatory and inhibitory synaptic inputs that originates at least partially from adaptation in the cone photoreceptors. More generally, this highlights how subtle asymmetries in signaling – here in the cone signals – can qualitatively alter circuit computation. eLife Sciences Publications, Ltd 2022-03-14 /pmc/articles/PMC8956286/ /pubmed/35285798 http://dx.doi.org/10.7554/eLife.70611 Text en © 2022, Yu et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Yu, Zhou
Turner, Maxwell H
Baudin, Jacob
Rieke, Fred
Adaptation in cone photoreceptors contributes to an unexpected insensitivity of primate On parasol retinal ganglion cells to spatial structure in natural images
title Adaptation in cone photoreceptors contributes to an unexpected insensitivity of primate On parasol retinal ganglion cells to spatial structure in natural images
title_full Adaptation in cone photoreceptors contributes to an unexpected insensitivity of primate On parasol retinal ganglion cells to spatial structure in natural images
title_fullStr Adaptation in cone photoreceptors contributes to an unexpected insensitivity of primate On parasol retinal ganglion cells to spatial structure in natural images
title_full_unstemmed Adaptation in cone photoreceptors contributes to an unexpected insensitivity of primate On parasol retinal ganglion cells to spatial structure in natural images
title_short Adaptation in cone photoreceptors contributes to an unexpected insensitivity of primate On parasol retinal ganglion cells to spatial structure in natural images
title_sort adaptation in cone photoreceptors contributes to an unexpected insensitivity of primate on parasol retinal ganglion cells to spatial structure in natural images
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956286/
https://www.ncbi.nlm.nih.gov/pubmed/35285798
http://dx.doi.org/10.7554/eLife.70611
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