Cargando…

Rumdul (Sphaerocoryne affinis) Antioxidant Activity and Its Potential for Parkinson's Disease Treatment

Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by progressive deterioration of motor function and loss of dopaminergic neurons in the substantia nigra. Although PD is more common in people over 60 years old, people with young-onset PD tend to increase recent...

Descripción completa

Detalles Bibliográficos
Autores principales: Nghi, Ngo Binh Thao, Uyen, Tran Thuc, Anh, Huynh Man, Linh, Dao My, Thao, Dang Thi Phuong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956402/
https://www.ncbi.nlm.nih.gov/pubmed/35340209
http://dx.doi.org/10.1155/2022/8918966
_version_ 1784676561068228608
author Nghi, Ngo Binh Thao
Uyen, Tran Thuc
Anh, Huynh Man
Linh, Dao My
Thao, Dang Thi Phuong
author_facet Nghi, Ngo Binh Thao
Uyen, Tran Thuc
Anh, Huynh Man
Linh, Dao My
Thao, Dang Thi Phuong
author_sort Nghi, Ngo Binh Thao
collection PubMed
description Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by progressive deterioration of motor function and loss of dopaminergic neurons in the substantia nigra. Although PD is more common in people over 60 years old, people with young-onset PD tend to increase recently. Up to now, there is no cure for PD; therapies mainly focus on reducing symptoms and improving patient quality of life. Thus, the requirement of exploring new medications is needed. There is a strong relationship between oxidative stress and PD. Therefore, antioxidant compounds have been considered as a novel therapy for PD. In this study, we indicated a new potential candidate for PD treatment, rumdul fruit (Sphaerocoryne affinis—a member of the Annonaceae family), due to evaluating its activities on the fly model of Parkinson. Our experimental results showed that rumdul fruit water extract (RFWE) has a strong antioxidant capacity with IC50 value in DPPH assay which was 85.62 ± 1.05 μg/mL. The use of RFWE at concentrations of 3, 6, and 12 mg/mL could strongly ameliorate the locomotor disabilities and dopaminergic neuron degeneration. Although the RFWE at high concentrations like 12 mg/mL and 18 mg/mL could induce some side effects on fly development and viability, our data strongly demonstrated that RFWE effectively rescued PD phenotypes on the fly model. Although component in the plant extract, as well as the molecular mechanism helping to recover the phenotype, has not been elucidated yet, the research contributed strong scientific evidence for further research on applying rumdul as a novel natural source for PD treatment.
format Online
Article
Text
id pubmed-8956402
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-89564022022-03-26 Rumdul (Sphaerocoryne affinis) Antioxidant Activity and Its Potential for Parkinson's Disease Treatment Nghi, Ngo Binh Thao Uyen, Tran Thuc Anh, Huynh Man Linh, Dao My Thao, Dang Thi Phuong Oxid Med Cell Longev Research Article Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by progressive deterioration of motor function and loss of dopaminergic neurons in the substantia nigra. Although PD is more common in people over 60 years old, people with young-onset PD tend to increase recently. Up to now, there is no cure for PD; therapies mainly focus on reducing symptoms and improving patient quality of life. Thus, the requirement of exploring new medications is needed. There is a strong relationship between oxidative stress and PD. Therefore, antioxidant compounds have been considered as a novel therapy for PD. In this study, we indicated a new potential candidate for PD treatment, rumdul fruit (Sphaerocoryne affinis—a member of the Annonaceae family), due to evaluating its activities on the fly model of Parkinson. Our experimental results showed that rumdul fruit water extract (RFWE) has a strong antioxidant capacity with IC50 value in DPPH assay which was 85.62 ± 1.05 μg/mL. The use of RFWE at concentrations of 3, 6, and 12 mg/mL could strongly ameliorate the locomotor disabilities and dopaminergic neuron degeneration. Although the RFWE at high concentrations like 12 mg/mL and 18 mg/mL could induce some side effects on fly development and viability, our data strongly demonstrated that RFWE effectively rescued PD phenotypes on the fly model. Although component in the plant extract, as well as the molecular mechanism helping to recover the phenotype, has not been elucidated yet, the research contributed strong scientific evidence for further research on applying rumdul as a novel natural source for PD treatment. Hindawi 2022-03-18 /pmc/articles/PMC8956402/ /pubmed/35340209 http://dx.doi.org/10.1155/2022/8918966 Text en Copyright © 2022 Ngo Binh Thao Nghi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nghi, Ngo Binh Thao
Uyen, Tran Thuc
Anh, Huynh Man
Linh, Dao My
Thao, Dang Thi Phuong
Rumdul (Sphaerocoryne affinis) Antioxidant Activity and Its Potential for Parkinson's Disease Treatment
title Rumdul (Sphaerocoryne affinis) Antioxidant Activity and Its Potential for Parkinson's Disease Treatment
title_full Rumdul (Sphaerocoryne affinis) Antioxidant Activity and Its Potential for Parkinson's Disease Treatment
title_fullStr Rumdul (Sphaerocoryne affinis) Antioxidant Activity and Its Potential for Parkinson's Disease Treatment
title_full_unstemmed Rumdul (Sphaerocoryne affinis) Antioxidant Activity and Its Potential for Parkinson's Disease Treatment
title_short Rumdul (Sphaerocoryne affinis) Antioxidant Activity and Its Potential for Parkinson's Disease Treatment
title_sort rumdul (sphaerocoryne affinis) antioxidant activity and its potential for parkinson's disease treatment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956402/
https://www.ncbi.nlm.nih.gov/pubmed/35340209
http://dx.doi.org/10.1155/2022/8918966
work_keys_str_mv AT nghingobinhthao rumdulsphaerocoryneaffinisantioxidantactivityanditspotentialforparkinsonsdiseasetreatment
AT uyentranthuc rumdulsphaerocoryneaffinisantioxidantactivityanditspotentialforparkinsonsdiseasetreatment
AT anhhuynhman rumdulsphaerocoryneaffinisantioxidantactivityanditspotentialforparkinsonsdiseasetreatment
AT linhdaomy rumdulsphaerocoryneaffinisantioxidantactivityanditspotentialforparkinsonsdiseasetreatment
AT thaodangthiphuong rumdulsphaerocoryneaffinisantioxidantactivityanditspotentialforparkinsonsdiseasetreatment