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Cyclic Thrombocytopenia: A Rare Cause of Recurrent Thrombocytopenia

Cyclic thrombocytopenia (CTP) is a very rare hematological disorder that is characterized by periodic fluctuations in platelet counts. Diagnosis is generally delayed due to its similarity with immune thrombocytopenia (ITP). The pathophysiology is unknown and there are currently no guidelines for man...

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Autores principales: Oyenuga, Mosunmoluwa, Onyechi, Afoma, Sartaj, Sara, Patel, Rushin, Sinha, Jyotsana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956483/
https://www.ncbi.nlm.nih.gov/pubmed/35345682
http://dx.doi.org/10.7759/cureus.22525
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author Oyenuga, Mosunmoluwa
Onyechi, Afoma
Sartaj, Sara
Patel, Rushin
Sinha, Jyotsana
author_facet Oyenuga, Mosunmoluwa
Onyechi, Afoma
Sartaj, Sara
Patel, Rushin
Sinha, Jyotsana
author_sort Oyenuga, Mosunmoluwa
collection PubMed
description Cyclic thrombocytopenia (CTP) is a very rare hematological disorder that is characterized by periodic fluctuations in platelet counts. Diagnosis is generally delayed due to its similarity with immune thrombocytopenia (ITP). The pathophysiology is unknown and there are currently no guidelines for management. Many patients are usually treated for ITP initially prior to diagnosis. We describe a 67-year-old female with a history of multiple episodes of transient thrombocytopenia who presented to the hospital with another episode of thrombocytopenia. Her workup including HIV, hepatitis screening, vitamin B12, and folate was negative. She received a unit of platelet transfusion and was later observed in the hospital. Further review of her chart showed similar episodes in the past with spontaneous improvement. She was diagnosed with CTP. Her platelet count improved remarkably prior to discharge. In patients with recurrent fluctuation in their platelet count, CTP should be one of the differentials as this might prevent further unnecessary therapies.
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spelling pubmed-89564832022-03-27 Cyclic Thrombocytopenia: A Rare Cause of Recurrent Thrombocytopenia Oyenuga, Mosunmoluwa Onyechi, Afoma Sartaj, Sara Patel, Rushin Sinha, Jyotsana Cureus Family/General Practice Cyclic thrombocytopenia (CTP) is a very rare hematological disorder that is characterized by periodic fluctuations in platelet counts. Diagnosis is generally delayed due to its similarity with immune thrombocytopenia (ITP). The pathophysiology is unknown and there are currently no guidelines for management. Many patients are usually treated for ITP initially prior to diagnosis. We describe a 67-year-old female with a history of multiple episodes of transient thrombocytopenia who presented to the hospital with another episode of thrombocytopenia. Her workup including HIV, hepatitis screening, vitamin B12, and folate was negative. She received a unit of platelet transfusion and was later observed in the hospital. Further review of her chart showed similar episodes in the past with spontaneous improvement. She was diagnosed with CTP. Her platelet count improved remarkably prior to discharge. In patients with recurrent fluctuation in their platelet count, CTP should be one of the differentials as this might prevent further unnecessary therapies. Cureus 2022-02-23 /pmc/articles/PMC8956483/ /pubmed/35345682 http://dx.doi.org/10.7759/cureus.22525 Text en Copyright © 2022, Oyenuga et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Family/General Practice
Oyenuga, Mosunmoluwa
Onyechi, Afoma
Sartaj, Sara
Patel, Rushin
Sinha, Jyotsana
Cyclic Thrombocytopenia: A Rare Cause of Recurrent Thrombocytopenia
title Cyclic Thrombocytopenia: A Rare Cause of Recurrent Thrombocytopenia
title_full Cyclic Thrombocytopenia: A Rare Cause of Recurrent Thrombocytopenia
title_fullStr Cyclic Thrombocytopenia: A Rare Cause of Recurrent Thrombocytopenia
title_full_unstemmed Cyclic Thrombocytopenia: A Rare Cause of Recurrent Thrombocytopenia
title_short Cyclic Thrombocytopenia: A Rare Cause of Recurrent Thrombocytopenia
title_sort cyclic thrombocytopenia: a rare cause of recurrent thrombocytopenia
topic Family/General Practice
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956483/
https://www.ncbi.nlm.nih.gov/pubmed/35345682
http://dx.doi.org/10.7759/cureus.22525
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