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Prognostic determinants of hearing outcomes in children with congenital cytomegalovirus infection

Congenital cytomegalovirus (cCMV) infection is the most prevalent cause of non-genetic sensorineural hearing loss (SNHL) in children. However, the prognostic determinants of SNHL remain unclear. Children with cCMV infection in a tertiary hospital were enrolled. The presence of cCMV-related symptoms...

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Autores principales: Lo, Ta-Hsuan, Lin, Pei-Hsuan, Hsu, Wei-Chung, Tsao, Po-Nien, Liu, Tien-Chen, Yang, Tzong-Hann, Hsu, Chuan-Jen, Huang, Li-Min, Lu, Chun-Yi, Wu, Chen-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956567/
https://www.ncbi.nlm.nih.gov/pubmed/35338167
http://dx.doi.org/10.1038/s41598-022-08392-w
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author Lo, Ta-Hsuan
Lin, Pei-Hsuan
Hsu, Wei-Chung
Tsao, Po-Nien
Liu, Tien-Chen
Yang, Tzong-Hann
Hsu, Chuan-Jen
Huang, Li-Min
Lu, Chun-Yi
Wu, Chen-Chi
author_facet Lo, Ta-Hsuan
Lin, Pei-Hsuan
Hsu, Wei-Chung
Tsao, Po-Nien
Liu, Tien-Chen
Yang, Tzong-Hann
Hsu, Chuan-Jen
Huang, Li-Min
Lu, Chun-Yi
Wu, Chen-Chi
author_sort Lo, Ta-Hsuan
collection PubMed
description Congenital cytomegalovirus (cCMV) infection is the most prevalent cause of non-genetic sensorineural hearing loss (SNHL) in children. However, the prognostic determinants of SNHL remain unclear. Children with cCMV infection in a tertiary hospital were enrolled. The presence of cCMV-related symptoms at birth, the newborn hearing screening (NHS) results, and the blood viral loads were ascertained. Audiologic outcomes and initial blood viral loads were compared between different groups. Of the 39 children enrolled, 16 developed SNHL. SNHL developed in 60% of children who were initially symptomatic, and in 34.5% of those who were initially asymptomatic with normal hearing or isolated hearing loss, respectively. Failuire in NHS was a reliable tool for early detection of SNHL. The initial viral loads were higher in children who were symptomatic at birth, those who failed NHS, and those who developed SNHL. We observed SNHL deterioration in a patient after CMV DNAemia clearance was achieved, and in another patient with the flare-up of viral load. The presence of cCMV-related symptoms at birth, failure in NHS, and blood viral load might be the prognostic factors for hearing outcomes. Regular audiologic examinations are necessary in all children with cCMV infection even after CMV DNAemia clearance.
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spelling pubmed-89565672022-03-28 Prognostic determinants of hearing outcomes in children with congenital cytomegalovirus infection Lo, Ta-Hsuan Lin, Pei-Hsuan Hsu, Wei-Chung Tsao, Po-Nien Liu, Tien-Chen Yang, Tzong-Hann Hsu, Chuan-Jen Huang, Li-Min Lu, Chun-Yi Wu, Chen-Chi Sci Rep Article Congenital cytomegalovirus (cCMV) infection is the most prevalent cause of non-genetic sensorineural hearing loss (SNHL) in children. However, the prognostic determinants of SNHL remain unclear. Children with cCMV infection in a tertiary hospital were enrolled. The presence of cCMV-related symptoms at birth, the newborn hearing screening (NHS) results, and the blood viral loads were ascertained. Audiologic outcomes and initial blood viral loads were compared between different groups. Of the 39 children enrolled, 16 developed SNHL. SNHL developed in 60% of children who were initially symptomatic, and in 34.5% of those who were initially asymptomatic with normal hearing or isolated hearing loss, respectively. Failuire in NHS was a reliable tool for early detection of SNHL. The initial viral loads were higher in children who were symptomatic at birth, those who failed NHS, and those who developed SNHL. We observed SNHL deterioration in a patient after CMV DNAemia clearance was achieved, and in another patient with the flare-up of viral load. The presence of cCMV-related symptoms at birth, failure in NHS, and blood viral load might be the prognostic factors for hearing outcomes. Regular audiologic examinations are necessary in all children with cCMV infection even after CMV DNAemia clearance. Nature Publishing Group UK 2022-03-25 /pmc/articles/PMC8956567/ /pubmed/35338167 http://dx.doi.org/10.1038/s41598-022-08392-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lo, Ta-Hsuan
Lin, Pei-Hsuan
Hsu, Wei-Chung
Tsao, Po-Nien
Liu, Tien-Chen
Yang, Tzong-Hann
Hsu, Chuan-Jen
Huang, Li-Min
Lu, Chun-Yi
Wu, Chen-Chi
Prognostic determinants of hearing outcomes in children with congenital cytomegalovirus infection
title Prognostic determinants of hearing outcomes in children with congenital cytomegalovirus infection
title_full Prognostic determinants of hearing outcomes in children with congenital cytomegalovirus infection
title_fullStr Prognostic determinants of hearing outcomes in children with congenital cytomegalovirus infection
title_full_unstemmed Prognostic determinants of hearing outcomes in children with congenital cytomegalovirus infection
title_short Prognostic determinants of hearing outcomes in children with congenital cytomegalovirus infection
title_sort prognostic determinants of hearing outcomes in children with congenital cytomegalovirus infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956567/
https://www.ncbi.nlm.nih.gov/pubmed/35338167
http://dx.doi.org/10.1038/s41598-022-08392-w
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