Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells

Patient-derived xenografts (PDX) are widely used as human cancer models. Previous studies demonstrated clonal discordance between PDX and primary cells. However, in acute myeloid leukemia (AML)-PDX models, the significance of the clonal dynamics occurring in PDX remains unclear. By evaluating change...

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Detalles Bibliográficos
Autores principales: Kawashima, Naomi, Ishikawa, Yuichi, Kim, Jeong Hui, Ushijima, Yoko, Akashi, Akimi, Yamaguchi, Yohei, Hattori, Hikaru, Nakashima, Marie, Ikeno, Seara, Kihara, Rika, Nishiyama, Takahiro, Morishita, Takanobu, Watamoto, Koichi, Ozawa, Yukiyasu, Kitamura, Kunio, Kiyoi, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956585/
https://www.ncbi.nlm.nih.gov/pubmed/35338146
http://dx.doi.org/10.1038/s41467-022-29304-6

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