Cargando…

Distribution and possible function of galanin about headache and immune system in the rat dura mater

Galanin (GAL) is a nociceptive transmitter or modulator in the trigeminal sensory system. In this study, GAL expression was investigated in the rat dura mater to demonstrate its possible function in headache using immunohistochemical techniques. The cerebral falx and cerebellar dura mater received a...

Descripción completa

Detalles Bibliográficos
Autores principales: Shimazaki, Kenichiro, Yajima, Takehiro, Ichikawa, Hiroyuki, Sato, Tadasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956595/
https://www.ncbi.nlm.nih.gov/pubmed/35338230
http://dx.doi.org/10.1038/s41598-022-09325-3
_version_ 1784676599235346432
author Shimazaki, Kenichiro
Yajima, Takehiro
Ichikawa, Hiroyuki
Sato, Tadasu
author_facet Shimazaki, Kenichiro
Yajima, Takehiro
Ichikawa, Hiroyuki
Sato, Tadasu
author_sort Shimazaki, Kenichiro
collection PubMed
description Galanin (GAL) is a nociceptive transmitter or modulator in the trigeminal sensory system. In this study, GAL expression was investigated in the rat dura mater to demonstrate its possible function in headache using immunohistochemical techniques. The cerebral falx and cerebellar dura mater received abundant blood and nerve supply, and were significantly thicker compared to other portions in the cerebral dura mater. GAL-immunoreactivity was expressed by cell and nerve fiber profiles. Presumed macrophages and dendritic cells contained GAL-immunoreactivity, and co-expressed with CD11b-immunoreactivity. Many isolated and perivascular nerve fibers also showed GAL-immunoreactivity. In addition, GAL-immunoreactive nerve fibers were present in the vicinity of macrophages and dendritic cells with either GAL- or ED1-immunoreactivity. GAL-immunoreactive cells and nerve fibers were common in the cerebral falx and cerebellar dura mater and infrequent in other portions. And, GAL-immunoreactive nerve fibers usually co-expressed calcitonin gene-related peptide (CGRP)-immunoreactivity. In the trigeminal ganglion, a substantial proportion of sensory neurons innervating the dura mater contained GAL-immunoreactivity (mean ± SD, 3.4 ± 2.2%), and co-expressed CGRP-immunoreactivity (2.7 ± 2.1%). The present study may suggest that GAL is associated with nociceptive transduction or modulation in the dura mater. GAL also possibly plays a role in the immune mechanism of the dura mater.
format Online
Article
Text
id pubmed-8956595
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-89565952022-03-28 Distribution and possible function of galanin about headache and immune system in the rat dura mater Shimazaki, Kenichiro Yajima, Takehiro Ichikawa, Hiroyuki Sato, Tadasu Sci Rep Article Galanin (GAL) is a nociceptive transmitter or modulator in the trigeminal sensory system. In this study, GAL expression was investigated in the rat dura mater to demonstrate its possible function in headache using immunohistochemical techniques. The cerebral falx and cerebellar dura mater received abundant blood and nerve supply, and were significantly thicker compared to other portions in the cerebral dura mater. GAL-immunoreactivity was expressed by cell and nerve fiber profiles. Presumed macrophages and dendritic cells contained GAL-immunoreactivity, and co-expressed with CD11b-immunoreactivity. Many isolated and perivascular nerve fibers also showed GAL-immunoreactivity. In addition, GAL-immunoreactive nerve fibers were present in the vicinity of macrophages and dendritic cells with either GAL- or ED1-immunoreactivity. GAL-immunoreactive cells and nerve fibers were common in the cerebral falx and cerebellar dura mater and infrequent in other portions. And, GAL-immunoreactive nerve fibers usually co-expressed calcitonin gene-related peptide (CGRP)-immunoreactivity. In the trigeminal ganglion, a substantial proportion of sensory neurons innervating the dura mater contained GAL-immunoreactivity (mean ± SD, 3.4 ± 2.2%), and co-expressed CGRP-immunoreactivity (2.7 ± 2.1%). The present study may suggest that GAL is associated with nociceptive transduction or modulation in the dura mater. GAL also possibly plays a role in the immune mechanism of the dura mater. Nature Publishing Group UK 2022-03-25 /pmc/articles/PMC8956595/ /pubmed/35338230 http://dx.doi.org/10.1038/s41598-022-09325-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Shimazaki, Kenichiro
Yajima, Takehiro
Ichikawa, Hiroyuki
Sato, Tadasu
Distribution and possible function of galanin about headache and immune system in the rat dura mater
title Distribution and possible function of galanin about headache and immune system in the rat dura mater
title_full Distribution and possible function of galanin about headache and immune system in the rat dura mater
title_fullStr Distribution and possible function of galanin about headache and immune system in the rat dura mater
title_full_unstemmed Distribution and possible function of galanin about headache and immune system in the rat dura mater
title_short Distribution and possible function of galanin about headache and immune system in the rat dura mater
title_sort distribution and possible function of galanin about headache and immune system in the rat dura mater
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956595/
https://www.ncbi.nlm.nih.gov/pubmed/35338230
http://dx.doi.org/10.1038/s41598-022-09325-3
work_keys_str_mv AT shimazakikenichiro distributionandpossiblefunctionofgalaninaboutheadacheandimmunesystemintheratduramater
AT yajimatakehiro distributionandpossiblefunctionofgalaninaboutheadacheandimmunesystemintheratduramater
AT ichikawahiroyuki distributionandpossiblefunctionofgalaninaboutheadacheandimmunesystemintheratduramater
AT satotadasu distributionandpossiblefunctionofgalaninaboutheadacheandimmunesystemintheratduramater