CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity

The cellular processes that govern tumor resistance to immunotherapy remain poorly understood. To gain insight into these processes, here we perform a genome-scale CRISPR activation screen for genes that enable human melanoma cells to evade cytotoxic T cell killing. Overexpression of four top candid...

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Detalles Bibliográficos
Autores principales: Joung, Julia, Kirchgatterer, Paul C., Singh, Ankita, Cho, Jang H., Nety, Suchita P., Larson, Rebecca C., Macrae, Rhiannon K., Deasy, Rebecca, Tseng, Yuen-Yi, Maus, Marcela V., Zhang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956604/
https://www.ncbi.nlm.nih.gov/pubmed/35338135
http://dx.doi.org/10.1038/s41467-022-29205-8

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