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Disrupted structural network of inferomedial temporal regions in relapsing–remitting multiple sclerosis compared with neuromyelitis optica spectrum disorder
Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are two representative chronic inflammatory demyelinating disorders of the central nervous system. We aimed to determine and compare the alterations of white matter (WM) connectivity between MS, NMOSD, and healthy controls (H...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956623/ https://www.ncbi.nlm.nih.gov/pubmed/35338192 http://dx.doi.org/10.1038/s41598-022-09065-4 |
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author | Cho, Eun Bin Kim, Daegyeom Jeong, ByeongChang Shin, Jong Hwa Chung, Yeon Hak Kim, Sung Tae Kim, Byoung Joon Han, Cheol E. Min, Ju-Hong |
author_facet | Cho, Eun Bin Kim, Daegyeom Jeong, ByeongChang Shin, Jong Hwa Chung, Yeon Hak Kim, Sung Tae Kim, Byoung Joon Han, Cheol E. Min, Ju-Hong |
author_sort | Cho, Eun Bin |
collection | PubMed |
description | Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are two representative chronic inflammatory demyelinating disorders of the central nervous system. We aimed to determine and compare the alterations of white matter (WM) connectivity between MS, NMOSD, and healthy controls (HC). This study included 68 patients with relapsing–remitting MS, 50 with NMOSD, and 26 HC. A network-based statistics method was used to assess disrupted patterns in WM networks. Topological characteristics of the three groups were compared and their associations with clinical parameters were examined. WM network analysis indicated that the MS and NMOSD groups had lower total strength, clustering coefficient, global efficiency, and local efficiency and had longer characteristic path length than HC, but there were no differences between the MS and NMOSD groups. At the nodal level, the MS group had more brain regions with altered network topologies than did the NMOSD group when compared with the HC group. Network alterations were correlated with Expanded Disability Status Scale score and disease duration in both MS and NMOSD groups. Two distinct subnetworks that characterized the disease groups were also identified. When compared with NMOSD, the most discriminative connectivity changes in MS were located between the thalamus, hippocampus, parahippocampal gyrus, amygdala, fusiform gyrus, and inferior and superior temporal gyri. In conclusion, MS patients had greater network dysfunction compared to NMOSD and altered short connections within the thalamus and inferomedial temporal regions were relatively spared in NMOSD compared with MS. |
format | Online Article Text |
id | pubmed-8956623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-89566232022-03-28 Disrupted structural network of inferomedial temporal regions in relapsing–remitting multiple sclerosis compared with neuromyelitis optica spectrum disorder Cho, Eun Bin Kim, Daegyeom Jeong, ByeongChang Shin, Jong Hwa Chung, Yeon Hak Kim, Sung Tae Kim, Byoung Joon Han, Cheol E. Min, Ju-Hong Sci Rep Article Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are two representative chronic inflammatory demyelinating disorders of the central nervous system. We aimed to determine and compare the alterations of white matter (WM) connectivity between MS, NMOSD, and healthy controls (HC). This study included 68 patients with relapsing–remitting MS, 50 with NMOSD, and 26 HC. A network-based statistics method was used to assess disrupted patterns in WM networks. Topological characteristics of the three groups were compared and their associations with clinical parameters were examined. WM network analysis indicated that the MS and NMOSD groups had lower total strength, clustering coefficient, global efficiency, and local efficiency and had longer characteristic path length than HC, but there were no differences between the MS and NMOSD groups. At the nodal level, the MS group had more brain regions with altered network topologies than did the NMOSD group when compared with the HC group. Network alterations were correlated with Expanded Disability Status Scale score and disease duration in both MS and NMOSD groups. Two distinct subnetworks that characterized the disease groups were also identified. When compared with NMOSD, the most discriminative connectivity changes in MS were located between the thalamus, hippocampus, parahippocampal gyrus, amygdala, fusiform gyrus, and inferior and superior temporal gyri. In conclusion, MS patients had greater network dysfunction compared to NMOSD and altered short connections within the thalamus and inferomedial temporal regions were relatively spared in NMOSD compared with MS. Nature Publishing Group UK 2022-03-25 /pmc/articles/PMC8956623/ /pubmed/35338192 http://dx.doi.org/10.1038/s41598-022-09065-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Cho, Eun Bin Kim, Daegyeom Jeong, ByeongChang Shin, Jong Hwa Chung, Yeon Hak Kim, Sung Tae Kim, Byoung Joon Han, Cheol E. Min, Ju-Hong Disrupted structural network of inferomedial temporal regions in relapsing–remitting multiple sclerosis compared with neuromyelitis optica spectrum disorder |
title | Disrupted structural network of inferomedial temporal regions in relapsing–remitting multiple sclerosis compared with neuromyelitis optica spectrum disorder |
title_full | Disrupted structural network of inferomedial temporal regions in relapsing–remitting multiple sclerosis compared with neuromyelitis optica spectrum disorder |
title_fullStr | Disrupted structural network of inferomedial temporal regions in relapsing–remitting multiple sclerosis compared with neuromyelitis optica spectrum disorder |
title_full_unstemmed | Disrupted structural network of inferomedial temporal regions in relapsing–remitting multiple sclerosis compared with neuromyelitis optica spectrum disorder |
title_short | Disrupted structural network of inferomedial temporal regions in relapsing–remitting multiple sclerosis compared with neuromyelitis optica spectrum disorder |
title_sort | disrupted structural network of inferomedial temporal regions in relapsing–remitting multiple sclerosis compared with neuromyelitis optica spectrum disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956623/ https://www.ncbi.nlm.nih.gov/pubmed/35338192 http://dx.doi.org/10.1038/s41598-022-09065-4 |
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