Complex roles of nicotinamide N-methyltransferase in cancer progression

Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which S-adenosyl-l-methionine (SAM) is the methyl donor. High expression of NNMT can alter cellular NAM and SAM levels, which in...

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Autores principales: Wang, Weixuan, Yang, Changmei, Wang, Tianxiang, Deng, Haiteng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956669/
https://www.ncbi.nlm.nih.gov/pubmed/35338115
http://dx.doi.org/10.1038/s41419-022-04713-z
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author Wang, Weixuan
Yang, Changmei
Wang, Tianxiang
Deng, Haiteng
author_facet Wang, Weixuan
Yang, Changmei
Wang, Tianxiang
Deng, Haiteng
author_sort Wang, Weixuan
collection PubMed
description Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which S-adenosyl-l-methionine (SAM) is the methyl donor. High expression of NNMT can alter cellular NAM and SAM levels, which in turn, affects nicotinamide adenine dinucleotide (NAD(+))-dependent redox reactions and signaling pathways, and remodels cellular epigenetic states. Studies have revealed that NNMT plays critical roles in the occurrence and development of various cancers, and analysis of NNMT expression levels in different cancers from The Cancer Genome Atlas (TCGA) dataset indicated that NNMT might be a potential biomarker and therapeutic target for tumor diagnosis and treatment. This review provides a comprehensive understanding of recent advances on NNMT functions in different tumors and deciphers the complex roles of NNMT in cancer progression.
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spelling pubmed-89566692022-04-11 Complex roles of nicotinamide N-methyltransferase in cancer progression Wang, Weixuan Yang, Changmei Wang, Tianxiang Deng, Haiteng Cell Death Dis Review Article Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which S-adenosyl-l-methionine (SAM) is the methyl donor. High expression of NNMT can alter cellular NAM and SAM levels, which in turn, affects nicotinamide adenine dinucleotide (NAD(+))-dependent redox reactions and signaling pathways, and remodels cellular epigenetic states. Studies have revealed that NNMT plays critical roles in the occurrence and development of various cancers, and analysis of NNMT expression levels in different cancers from The Cancer Genome Atlas (TCGA) dataset indicated that NNMT might be a potential biomarker and therapeutic target for tumor diagnosis and treatment. This review provides a comprehensive understanding of recent advances on NNMT functions in different tumors and deciphers the complex roles of NNMT in cancer progression. Nature Publishing Group UK 2022-03-25 /pmc/articles/PMC8956669/ /pubmed/35338115 http://dx.doi.org/10.1038/s41419-022-04713-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Wang, Weixuan
Yang, Changmei
Wang, Tianxiang
Deng, Haiteng
Complex roles of nicotinamide N-methyltransferase in cancer progression
title Complex roles of nicotinamide N-methyltransferase in cancer progression
title_full Complex roles of nicotinamide N-methyltransferase in cancer progression
title_fullStr Complex roles of nicotinamide N-methyltransferase in cancer progression
title_full_unstemmed Complex roles of nicotinamide N-methyltransferase in cancer progression
title_short Complex roles of nicotinamide N-methyltransferase in cancer progression
title_sort complex roles of nicotinamide n-methyltransferase in cancer progression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956669/
https://www.ncbi.nlm.nih.gov/pubmed/35338115
http://dx.doi.org/10.1038/s41419-022-04713-z
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