Cargando…

Complex roles of nicotinamide N-methyltransferase in cancer progression

Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which S-adenosyl-l-methionine (SAM) is the methyl donor. High expression of NNMT can alter cellular NAM and SAM levels, which in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Weixuan, Yang, Changmei, Wang, Tianxiang, Deng, Haiteng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956669/ https://www.ncbi.nlm.nih.gov/pubmed/35338115 http://dx.doi.org/10.1038/s41419-022-04713-z

Ejemplares similares

Nicotinamide N-Methyltransferase Remodeled Cell Metabolism and Aggravated Proinflammatory Responses by Activating STAT3/IL1β/PGE(2) Pathway
por: Yang, Changmei, et al.
Publicado: (2022)

Nicotinamide N-Methyltransferase in Health and Cancer
por: Ramsden, David B, et al.
Publicado: (2017)

Nicotinamide N-methyltransferase and liver diseases
por: Liang, Guangyu, et al.
Publicado: (2022)

Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N-Methyltransferase as a Biomarker in Skin Cancers
por: Campagna, Roberto, et al.
Publicado: (2021)

Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes
por: Liu, Jie-Ru, et al.
Publicado: (2021)

Overexpression of 15-Hydroxyprostaglandin Dehydrogenase Inhibits A549 Lung Adenocarcinoma Cell Growth via Inducing Cell Cycle Arrest and Inhibiting Epithelial-Mesenchymal Transition
por: Wang, Weixuan, et al.
Publicado: (2021)

Nicotinamide N-Methyltransferase: Genomic Connection to Disease
por: Ramsden, David B, et al.
Publicado: (2020)

Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1
por: You, Zhenyu, et al.
Publicado: (2018)

Systematic pan-cancer analysis of the nicotinamide n-methyltransferase in human cancer
por: Cao, Li, et al.
Publicado: (2022)

Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution
por: Parsons, Richard B., et al.
Publicado: (2021)

Nicotinamide N-Methyltransferase as Promising Tool for Management of Gastrointestinal Neoplasms
por: Pozzi, Valentina, et al.
Publicado: (2022)

Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer
por: Novak Kujundžić, Renata, et al.
Publicado: (2021)

Elucidating the role of nicotinamide N-methyltransferase-p53 axis in the progression of chronic kidney disease
por: Zhen, Xin, et al.
Publicado: (2023)

Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation
por: Roberti, Annalisa, et al.
Publicado: (2021)

Nicotinamide N-Methyltransferase in Head and Neck Tumors: A Comprehensive Review
por: Togni, Lucrezia, et al.
Publicado: (2021)

Nicotinamide Mononucleotide Alleviates LPS-Induced Inflammation and Oxidative Stress via Decreasing COX-2 Expression in Macrophages
por: Liu, Jing, et al.
Publicado: (2021)

Nicotinamide N-methyltransferase is overexpressed in prostate cancer and correlates with prolonged progression-free and overall survival times
por: ZHOU, WEIMIN, et al.
Publicado: (2014)

Novel Inhibitors of Nicotinamide-N-Methyltransferase for the Treatment of Metabolic Disorders
por: Kannt, Aimo, et al.
Publicado: (2021)

Targeting nicotinamide N-methyltransferase overcomes resistance to EGFR-TKI in non-small cell lung cancer cells
por: Wang, Jun, et al.
Publicado: (2022)

Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity
por: Gao, Yongzhi, et al.
Publicado: (2019)

Macrocyclic peptides as allosteric inhibitors of nicotinamide N-methyltransferase (NNMT)
por: van Haren, Matthijs J., et al.
Publicado: (2021)

Nicotinamide N-Methyltransferase Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric Cancer
por: Wu, Miaowei, et al.
Publicado: (2020)

The Utility of Nicotinamide N-Methyltransferase as a Potential Biomarker to Predict the Oncological Outcomes for Urological Cancers: An Update
por: Campagna, Roberto, et al.
Publicado: (2021)

Nicotinamide N-Methyltransferase: A Promising Biomarker and Target for Human Cancer Therapy
por: Li, Xiao-Yu, et al.
Publicado: (2022)

Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization
por: Wang, Yanzhong, et al.
Publicado: (2019)

The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease
por: Takahashi, Rina, et al.
Publicado: (2022)

Nicotinamide-N-Methyltransferase gene rs694539 variant and migraine risk
por: Sazci, Ali, et al.
Publicado: (2016)

High Expression of Nicotinamide N-Methyltransferase in Patients with Sporadic Alzheimer’s Disease
por: Kocinaj, Altin, et al.
Publicado: (2021)

Nicotinamide N-methyltransferase mediates lipofibroblast–myofibroblast transition and apoptosis resistance
por: Rehan, Mohammad, et al.
Publicado: (2023)

Physiological Study on Association between Nicotinamide N-Methyltransferase Gene Polymorphisms and Hyperlipidemia
por: Zhu, Xiao-Juan, et al.
Publicado: (2016)

Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis
por: Kim, Jongmin, et al.
Publicado: (2009)

Nicotinamide N‐methyltransferase is related to MELF pattern invasion in endometrioid carcinoma
por: Tahara, Shinichiro, et al.
Publicado: (2021)

High stromal nicotinamide N‐methyltransferase (NNMT) indicates poor prognosis in colorectal cancer
por: Song, Mengmeng, et al.
Publicado: (2020)

A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
por: Kannt, Aimo, et al.
Publicado: (2018)

Nicotinamide N-methyltransferase induces the proliferation and invasion of squamous cell carcinoma cells
por: Hah, Young-Sool, et al.
Publicado: (2019)

Linkage of nanosecond protein motion with enzymatic methyl transfer by nicotinamide N-methyltransferase
por: JING, Yahui, et al.
Publicado: (2021)

Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy
por: Schmeisser, Kathrin, et al.
Publicado: (2018)

Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase
por: Mizuno, Rin, et al.
Publicado: (2022)

Prognostic value of nicotinamide N-methyltransferase in human cancers: Evidence from a meta-analysis and database validation
por: Dang, Ling, et al.
Publicado: (2022)

Overexpression of Nicotinamide N-methyltransferase mainly covers stroma of colorectal cancer and correlates with unfavorable survival by its product 1-MNA
por: Yang, Jun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hhpomttud9nu2s1dpba9c9g3fq