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Phosphodiesterase 2A inhibition corrects the aberrant behavioral traits observed in genetic and environmental preclinical models of Autism Spectrum Disorder
Pharmacological inhibition of phosphodiesterase 2A (PDE2A), which catalyzes the hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), has recently been proposed as a novel therapeutic tool for Fragile X Syndrome (FXS), the leading monogenic cause of Autism Sp...
Autores principales: | Schiavi, Sara, Carbone, Emilia, Melancia, Francesca, di Masi, Alessandra, Jarjat, Marielle, Brau, Fréderic, Cardarelli, Silvia, Giorgi, Mauro, Bardoni, Barbara, Trezza, Viviana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956682/ https://www.ncbi.nlm.nih.gov/pubmed/35338117 http://dx.doi.org/10.1038/s41398-022-01885-2 |
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