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The landscape of receptor-mediated precision cancer combination therapy via a single-cell perspective

Mining a large cohort of single-cell transcriptomics data, here we employ combinatorial optimization techniques to chart the landscape of optimal combination therapies in cancer. We assume that each individual therapy can target any one of 1269 genes encoding cell surface receptors, which may be tar...

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Detalles Bibliográficos
Autores principales:	Ahmadi, Saba, Sukprasert, Pattara, Vegesna, Rahulsimham, Sinha, Sanju, Schischlik, Fiorella, Artzi, Natalie, Khuller, Samir, Schäffer, Alejandro A., Ruppin, Eytan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956718/ https://www.ncbi.nlm.nih.gov/pubmed/35338126 http://dx.doi.org/10.1038/s41467-022-29154-2

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