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Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers

Loss of expression or activity of the tumor suppressor PTEN acts similarly to an activating mutation in the oncogene PIK3CA in elevating intracellular levels of phosphatidylinositol (3,4,5)-trisphosphate (PIP3), inducing signaling by AKT and other pro-tumorigenic signaling proteins. Here, we analyze...

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Detalles Bibliográficos
Autores principales:	Serebriiskii, Ilya G., Pavlov, Valery, Tricarico, Rossella, Andrianov, Grigorii, Nicolas, Emmanuelle, Parker, Mitchell I., Newberg, Justin, Frampton, Garrett, Meyer, Joshua E., Golemis, Erica A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956741/ https://www.ncbi.nlm.nih.gov/pubmed/35338148 http://dx.doi.org/10.1038/s41467-022-29227-2

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