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Antifungal activity of Rhopalurus crassicauda venom against Candida spp.
Fungal infections are becoming a serious problem of human diseases, being one of the most important fungal pathogens the yeast of the genus Candida. So far, fungal infection treatment faces different challenges, including the limited number of therapeutic drugs. Scorpions are known to be a valuable...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956938/ https://www.ncbi.nlm.nih.gov/pubmed/35345480 http://dx.doi.org/10.1016/j.toxcx.2022.100120 |
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author | Zottich, Umberto de Oliveira, Isadora Sousa Fereira, Isabela Gobbo Cerni, Felipe Augusto Karla de Castro Figueiredo, Bordon Arantes, Eliane Candiani Gomes, Valdirene Moreira Dias, Germana Bueno Pucca, Manuela Berto |
author_facet | Zottich, Umberto de Oliveira, Isadora Sousa Fereira, Isabela Gobbo Cerni, Felipe Augusto Karla de Castro Figueiredo, Bordon Arantes, Eliane Candiani Gomes, Valdirene Moreira Dias, Germana Bueno Pucca, Manuela Berto |
author_sort | Zottich, Umberto |
collection | PubMed |
description | Fungal infections are becoming a serious problem of human diseases, being one of the most important fungal pathogens the yeast of the genus Candida. So far, fungal infection treatment faces different challenges, including the limited number of therapeutic drugs. Scorpions are known to be a valuable source of biologically active molecules, especially of peptide-derived molecules with a variety of biological effects and useful, lead compounds for drugs development. Here, we pioneer described the antifungal effect of venom, mucus, and the major toxin (Rc1) from Rhopalurus crassicauda scorpion. These results support the potential for Rc1 to be further investigated as a novel antifungal therapeutic to treat Candida infections. |
format | Online Article Text |
id | pubmed-8956938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-89569382022-03-27 Antifungal activity of Rhopalurus crassicauda venom against Candida spp. Zottich, Umberto de Oliveira, Isadora Sousa Fereira, Isabela Gobbo Cerni, Felipe Augusto Karla de Castro Figueiredo, Bordon Arantes, Eliane Candiani Gomes, Valdirene Moreira Dias, Germana Bueno Pucca, Manuela Berto Toxicon X Toxins from venomous and poisonous animal Fungal infections are becoming a serious problem of human diseases, being one of the most important fungal pathogens the yeast of the genus Candida. So far, fungal infection treatment faces different challenges, including the limited number of therapeutic drugs. Scorpions are known to be a valuable source of biologically active molecules, especially of peptide-derived molecules with a variety of biological effects and useful, lead compounds for drugs development. Here, we pioneer described the antifungal effect of venom, mucus, and the major toxin (Rc1) from Rhopalurus crassicauda scorpion. These results support the potential for Rc1 to be further investigated as a novel antifungal therapeutic to treat Candida infections. Elsevier 2022-03-23 /pmc/articles/PMC8956938/ /pubmed/35345480 http://dx.doi.org/10.1016/j.toxcx.2022.100120 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Toxins from venomous and poisonous animal Zottich, Umberto de Oliveira, Isadora Sousa Fereira, Isabela Gobbo Cerni, Felipe Augusto Karla de Castro Figueiredo, Bordon Arantes, Eliane Candiani Gomes, Valdirene Moreira Dias, Germana Bueno Pucca, Manuela Berto Antifungal activity of Rhopalurus crassicauda venom against Candida spp. |
title | Antifungal activity of Rhopalurus crassicauda venom against Candida spp. |
title_full | Antifungal activity of Rhopalurus crassicauda venom against Candida spp. |
title_fullStr | Antifungal activity of Rhopalurus crassicauda venom against Candida spp. |
title_full_unstemmed | Antifungal activity of Rhopalurus crassicauda venom against Candida spp. |
title_short | Antifungal activity of Rhopalurus crassicauda venom against Candida spp. |
title_sort | antifungal activity of rhopalurus crassicauda venom against candida spp. |
topic | Toxins from venomous and poisonous animal |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956938/ https://www.ncbi.nlm.nih.gov/pubmed/35345480 http://dx.doi.org/10.1016/j.toxcx.2022.100120 |
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