Investigation of the pH-dependent aggregation mechanisms of GCSF using low resolution protein characterization techniques and advanced molecular dynamics simulations

Granulocyte-colony stimulating factor (GCSF) is a widely used therapeutic protein to treat neutropenia. GCSF has an increased propensity to aggregate if the pH is increased above 5.0. Although GCSF is very well experimentally characterized, the exact pH-dependent aggregation mechanism of GCSF is sti...

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Detalles Bibliográficos
Autores principales: Ko, Suk Kyu, Berner, Carolin, Kulakova, Alina, Schneider, Markus, Antes, Iris, Winter, Gerhard, Harris, Pernille, Peters, Günther H.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956964/
https://www.ncbi.nlm.nih.gov/pubmed/35386098
http://dx.doi.org/10.1016/j.csbj.2022.03.012

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