An etanercept O-glycovariant with enhanced potency

Most therapeutic proteins are glycosylated with N-glycans and/or O-glycans. N-glycans on therapeutic proteins have been extensively studied for their control strategy and impact on drug product quality. However, knowledge of O-glycosylation in therapeutic protein production and its impact on product...

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Detalles Bibliográficos
Autores principales: Biel, Thomas G., Faison, Talia, Matthews, Alicia M., Zou, Guozhang, Ortega-Rodriguez, Uriel, Pegues, Melissa A., Azer, Nicole, Gomez, Fabiola, Johnson, Sarah, Rogstad, Sarah, Chen, Kang, Xie, Hang, Agarabi, Cyrus, Rao, V. Ashutosh, Ju, Tongzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957051/
https://www.ncbi.nlm.nih.gov/pubmed/35402630
http://dx.doi.org/10.1016/j.omtm.2022.03.002

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