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Optimization in Chemical Modification of Single-Stranded siRNA Encapsulated by Neutral Cytidinyl/Cationic Lipids

Single-stranded siRNA (ss-siRNA) refers to the antisense strand of siRNA, which plays the role of gene silencing. Since single-stranded RNA is unstable, the present study employed a homemade neutral cytidinyl/cationic lipid delivery system and chemical modifications to improve its stability. The res...

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Detalles Bibliográficos
Autores principales:	Li, Zheng, Wang, Xixian, Zhou, Xinyang, Wang, Jie, Guan, Zhu, Yang, Zhenjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957067/ https://www.ncbi.nlm.nih.gov/pubmed/35345539 http://dx.doi.org/10.3389/fchem.2022.843181

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