Cargando…

Alteration in Functional Magnetic Resonance Imaging Signal Complexity Across Multiple Time Scales in Patients With Migraine Without Aura

BACKGROUND: Migraine is a primary neurological disorder associated with complex brain activity. Recently, mounting evidence has suggested that migraine is underpinned by aberrant dynamic brain activity characterized by linear and non-linear changes across a variety of time scales. However, the abnor...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Xiao, Zhang, Yutong, Qi, Wenchuan, Xu, Tao, Wang, Ziwen, Liao, Huaqiang, Wang, Yanan, Liu, Jie, Yu, Yang, He, Zhenxi, Gao, Shan, Li, Dehua, Zhang, Guilin, Zhao, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957082/
https://www.ncbi.nlm.nih.gov/pubmed/35345545
http://dx.doi.org/10.3389/fnins.2022.825172
_version_ 1784676694765862912
author Wang, Xiao
Zhang, Yutong
Qi, Wenchuan
Xu, Tao
Wang, Ziwen
Liao, Huaqiang
Wang, Yanan
Liu, Jie
Yu, Yang
He, Zhenxi
Gao, Shan
Li, Dehua
Zhang, Guilin
Zhao, Ling
author_facet Wang, Xiao
Zhang, Yutong
Qi, Wenchuan
Xu, Tao
Wang, Ziwen
Liao, Huaqiang
Wang, Yanan
Liu, Jie
Yu, Yang
He, Zhenxi
Gao, Shan
Li, Dehua
Zhang, Guilin
Zhao, Ling
author_sort Wang, Xiao
collection PubMed
description BACKGROUND: Migraine is a primary neurological disorder associated with complex brain activity. Recently, mounting evidence has suggested that migraine is underpinned by aberrant dynamic brain activity characterized by linear and non-linear changes across a variety of time scales. However, the abnormal dynamic brain activity at different time scales is still unknown in patients with migraine without aura (MWoA). This study aimed to assess the altered patterns of brain activity dynamics over different time scales and the potential pathophysiological mechanisms of alterations in patients with MWoA. METHODS: Multiscale entropy in 50 patients and 20 healthy controls (HCs) was calculated to investigate the patterns and altered brain complexity (BC) across five different time scales. Spearman rank correlation analysis between BC in regions showing significant intergroup differences and clinical scores (i.e., frequency of migraine attacks, duration, headache impact test) was conducted in patients with MWoA. RESULTS: The spatial distribution of BC varied across different time scales. At time scale1, BC was higher in the posterior default mode network (DMN) across participants. Compared with HCs, patients with MWoA had higher BC in the DMN and sensorimotor network. At time scale2, BC was mainly higher in the anterior DMN across participants. Patients with MWoA had higher BC in the sensorimotor network. At time scale3, BC was mainly higher in the frontoparietal network across participants. Patients with MWoA had increased BC in the parietal gyrus. At time scale4, BC is mainly higher in the sensorimotor network. Patients with MWoA had higher BC in the postcentral gyrus. At time scale5, BC was mainly higher in the DMN. Patients with MWoA had lower BC in the posterior DMN. In particular, BC values in the precuneus and paracentral lobule significantly correlated with clinical symptoms. CONCLUSION: Migraine is associated with alterations in dynamic brain activity in the sensorimotor network and DMN over multiple time scales. Time-varying BC within these regions could be linked to instability in pain transmission and modulation. Our findings provide new evidence for the hypothesis of abnormal dynamic brain activity in migraine.
format Online
Article
Text
id pubmed-8957082
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89570822022-03-27 Alteration in Functional Magnetic Resonance Imaging Signal Complexity Across Multiple Time Scales in Patients With Migraine Without Aura Wang, Xiao Zhang, Yutong Qi, Wenchuan Xu, Tao Wang, Ziwen Liao, Huaqiang Wang, Yanan Liu, Jie Yu, Yang He, Zhenxi Gao, Shan Li, Dehua Zhang, Guilin Zhao, Ling Front Neurosci Neuroscience BACKGROUND: Migraine is a primary neurological disorder associated with complex brain activity. Recently, mounting evidence has suggested that migraine is underpinned by aberrant dynamic brain activity characterized by linear and non-linear changes across a variety of time scales. However, the abnormal dynamic brain activity at different time scales is still unknown in patients with migraine without aura (MWoA). This study aimed to assess the altered patterns of brain activity dynamics over different time scales and the potential pathophysiological mechanisms of alterations in patients with MWoA. METHODS: Multiscale entropy in 50 patients and 20 healthy controls (HCs) was calculated to investigate the patterns and altered brain complexity (BC) across five different time scales. Spearman rank correlation analysis between BC in regions showing significant intergroup differences and clinical scores (i.e., frequency of migraine attacks, duration, headache impact test) was conducted in patients with MWoA. RESULTS: The spatial distribution of BC varied across different time scales. At time scale1, BC was higher in the posterior default mode network (DMN) across participants. Compared with HCs, patients with MWoA had higher BC in the DMN and sensorimotor network. At time scale2, BC was mainly higher in the anterior DMN across participants. Patients with MWoA had higher BC in the sensorimotor network. At time scale3, BC was mainly higher in the frontoparietal network across participants. Patients with MWoA had increased BC in the parietal gyrus. At time scale4, BC is mainly higher in the sensorimotor network. Patients with MWoA had higher BC in the postcentral gyrus. At time scale5, BC was mainly higher in the DMN. Patients with MWoA had lower BC in the posterior DMN. In particular, BC values in the precuneus and paracentral lobule significantly correlated with clinical symptoms. CONCLUSION: Migraine is associated with alterations in dynamic brain activity in the sensorimotor network and DMN over multiple time scales. Time-varying BC within these regions could be linked to instability in pain transmission and modulation. Our findings provide new evidence for the hypothesis of abnormal dynamic brain activity in migraine. Frontiers Media S.A. 2022-03-07 /pmc/articles/PMC8957082/ /pubmed/35345545 http://dx.doi.org/10.3389/fnins.2022.825172 Text en Copyright © 2022 Wang, Zhang, Qi, Xu, Wang, Liao, Wang, Liu, Yu, He, Gao, Li, Zhang and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Xiao
Zhang, Yutong
Qi, Wenchuan
Xu, Tao
Wang, Ziwen
Liao, Huaqiang
Wang, Yanan
Liu, Jie
Yu, Yang
He, Zhenxi
Gao, Shan
Li, Dehua
Zhang, Guilin
Zhao, Ling
Alteration in Functional Magnetic Resonance Imaging Signal Complexity Across Multiple Time Scales in Patients With Migraine Without Aura
title Alteration in Functional Magnetic Resonance Imaging Signal Complexity Across Multiple Time Scales in Patients With Migraine Without Aura
title_full Alteration in Functional Magnetic Resonance Imaging Signal Complexity Across Multiple Time Scales in Patients With Migraine Without Aura
title_fullStr Alteration in Functional Magnetic Resonance Imaging Signal Complexity Across Multiple Time Scales in Patients With Migraine Without Aura
title_full_unstemmed Alteration in Functional Magnetic Resonance Imaging Signal Complexity Across Multiple Time Scales in Patients With Migraine Without Aura
title_short Alteration in Functional Magnetic Resonance Imaging Signal Complexity Across Multiple Time Scales in Patients With Migraine Without Aura
title_sort alteration in functional magnetic resonance imaging signal complexity across multiple time scales in patients with migraine without aura
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957082/
https://www.ncbi.nlm.nih.gov/pubmed/35345545
http://dx.doi.org/10.3389/fnins.2022.825172
work_keys_str_mv AT wangxiao alterationinfunctionalmagneticresonanceimagingsignalcomplexityacrossmultipletimescalesinpatientswithmigrainewithoutaura
AT zhangyutong alterationinfunctionalmagneticresonanceimagingsignalcomplexityacrossmultipletimescalesinpatientswithmigrainewithoutaura
AT qiwenchuan alterationinfunctionalmagneticresonanceimagingsignalcomplexityacrossmultipletimescalesinpatientswithmigrainewithoutaura
AT xutao alterationinfunctionalmagneticresonanceimagingsignalcomplexityacrossmultipletimescalesinpatientswithmigrainewithoutaura
AT wangziwen alterationinfunctionalmagneticresonanceimagingsignalcomplexityacrossmultipletimescalesinpatientswithmigrainewithoutaura
AT liaohuaqiang alterationinfunctionalmagneticresonanceimagingsignalcomplexityacrossmultipletimescalesinpatientswithmigrainewithoutaura
AT wangyanan alterationinfunctionalmagneticresonanceimagingsignalcomplexityacrossmultipletimescalesinpatientswithmigrainewithoutaura
AT liujie alterationinfunctionalmagneticresonanceimagingsignalcomplexityacrossmultipletimescalesinpatientswithmigrainewithoutaura
AT yuyang alterationinfunctionalmagneticresonanceimagingsignalcomplexityacrossmultipletimescalesinpatientswithmigrainewithoutaura
AT hezhenxi alterationinfunctionalmagneticresonanceimagingsignalcomplexityacrossmultipletimescalesinpatientswithmigrainewithoutaura
AT gaoshan alterationinfunctionalmagneticresonanceimagingsignalcomplexityacrossmultipletimescalesinpatientswithmigrainewithoutaura
AT lidehua alterationinfunctionalmagneticresonanceimagingsignalcomplexityacrossmultipletimescalesinpatientswithmigrainewithoutaura
AT zhangguilin alterationinfunctionalmagneticresonanceimagingsignalcomplexityacrossmultipletimescalesinpatientswithmigrainewithoutaura
AT zhaoling alterationinfunctionalmagneticresonanceimagingsignalcomplexityacrossmultipletimescalesinpatientswithmigrainewithoutaura